OBJECTIVE: To determine the effects of recombinant human erythropoietin (rhEPO) on functional outcome and disability of patients with traumatic cervical spinal cord injury (SCI). METHODS: This was a randomized, double blind, placebo controlled clinical trial being performed in Nemazee and Shahid Rajaei hospitals of Shiraz during a 3-year period from 2011 to 2014. A total number of 20 patients with acute traumatic cervical SCI less than 8 hours after injury were included. We excluded those with anatomic cord dissection, penetrating cord injury and significant concomitant injury. Patients were randomly assigned to receive rhEPO in 500IU/mL dosage immediately and 24-hour later (n=11) or placebo (n=9). All the patient received standard regimen of methylprednisolone. Neurological function was assessed on admission, 1, 6 and 12 months after the injury according to the American Spinal Cord Injury Association (ASIA). RESULTS: Overall we include a total number of 20 patients. The mean age of the patients was found to be 40.1±9.5 (ranging from 19 to 59) years. There were 18 (90.0%) men and 2 (10.0%) women among the patients. There was no significant difference between two study groups regarding the baseline characteristics. The baseline ASIA score was comparable between two study groups. The motor and sensory ASIA scores were comparable between two study groups after 1, 6 and 12 months follow-ups. We also found that there was no significant difference between two study groups regarding the motor and sensory outcome in complete cord injury and incomplete cord injury subgroups. CONCLUSION: Administration of rhEPO does not improve the functional outcome of patients with traumatic cervical SCI.
RCT Entities:
OBJECTIVE: To determine the effects of recombinant humanerythropoietin (rhEPO) on functional outcome and disability of patients with traumatic cervical spinal cord injury (SCI). METHODS: This was a randomized, double blind, placebo controlled clinical trial being performed in Nemazee and Shahid Rajaei hospitals of Shiraz during a 3-year period from 2011 to 2014. A total number of 20 patients with acute traumatic cervical SCI less than 8 hours after injury were included. We excluded those with anatomic cord dissection, penetrating cord injury and significant concomitant injury. Patients were randomly assigned to receive rhEPO in 500IU/mL dosage immediately and 24-hour later (n=11) or placebo (n=9). All the patient received standard regimen of methylprednisolone. Neurological function was assessed on admission, 1, 6 and 12 months after the injury according to the American Spinal Cord Injury Association (ASIA). RESULTS: Overall we include a total number of 20 patients. The mean age of the patients was found to be 40.1±9.5 (ranging from 19 to 59) years. There were 18 (90.0%) men and 2 (10.0%) women among the patients. There was no significant difference between two study groups regarding the baseline characteristics. The baseline ASIA score was comparable between two study groups. The motor and sensory ASIA scores were comparable between two study groups after 1, 6 and 12 months follow-ups. We also found that there was no significant difference between two study groups regarding the motor and sensory outcome in complete cord injury and incomplete cord injury subgroups. CONCLUSION: Administration of rhEPO does not improve the functional outcome of patients with traumatic cervical SCI.
Authors: A L Sirén; M Fratelli; M Brines; C Goemans; S Casagrande; P Lewczuk; S Keenan; C Gleiter; C Pasquali; A Capobianco; T Mennini; R Heumann; A Cerami; H Ehrenreich; P Ghezzi Journal: Proc Natl Acad Sci U S A Date: 2001-03-20 Impact factor: 11.205
Authors: M B Bracken; M J Shepard; T R Holford; L Leo-Summers; E F Aldrich; M Fazl; M Fehlings; D L Herr; P W Hitchon; L F Marshall; R P Nockels; V Pascale; P L Perot; J Piepmeier; V K Sonntag; F Wagner; J E Wilberger; H R Winn; W Young Journal: JAMA Date: 1997-05-28 Impact factor: 56.272
Authors: S Sela; R Shurtz-Swirski; R Sharon; J Manaster; J Chezar; G Shkolnik; G Shapiro; S M Shasha; S Merchav; B Kristal Journal: Nephron Date: 2001-07 Impact factor: 2.847
Authors: Michael M Priebe; Anthony E Chiodo; William M Scelza; Steven C Kirshblum; Lisa-Ann Wuermser; Chester H Ho Journal: Arch Phys Med Rehabil Date: 2007-03 Impact factor: 3.966
Authors: M B Bracken; M J Shepard; K G Hellenbrand; W F Collins; L S Leo; D F Freeman; F C Wagner; E S Flamm; H M Eisenberg; J H Goodman Journal: J Neurosurg Date: 1985-11 Impact factor: 5.115
Authors: Georg Zimmermann; Lisa-Maria Bolter; Ronny Sluka; Yvonne Höller; Arne C Bathke; Aljoscha Thomschewski; Stefan Leis; Simona Lattanzi; Francesco Brigo; Eugen Trinka Journal: J Evid Based Med Date: 2019-06-23