Nora Sundahl1, Gert De Meerleer1, Geert Villeirs2, Piet Ost1, Wilfried De Neve1, Nicolaas Lumen3, Pieter De Visschere2, Marc Van Eijkeren1, Valérie Fonteyne4. 1. Ghent University Hospital, Department of Radiation Oncology and Experimental Cancer Research, Belgium. 2. Ghent University Hospital, Department of Radiology, Belgium. 3. Ghent University Hospital, Department of Urology, Belgium. 4. Ghent University Hospital, Department of Radiation Oncology and Experimental Cancer Research, Belgium. Electronic address: Valerie.fonteyne@uzgent.be.
Abstract
BACKGROUND AND PURPOSE: Local recurrences after radiotherapy are dose-dependent and occur in the dominant intraprostatic lesion (DIL). The purpose of this study was to evaluate the impact of a simultaneous integrated boost (SIB) to the magnetic resonance imaging (MRI)-defined DIL on toxicity. MATERIALS AND METHODS: Four-hundred and ten patients were treated with intensity-modulated radiotherapy. A median dose of 78Gy was prescribed to the prostate. A SIB of 82Gy to the DIL was performed in 225 patients (SIB+). Genitourinary and rectal toxicity on fixed time points up to 8years were compared between SIB- (185 patients) and SIB+ patients. Chi-square, Fisher's exact and Kaplan-Meier statistics were applied. With a median follow up of 72months, the six-year actuarial risk of genitourinary and rectal toxicity grade⩾2 was 31% and 12% respectively. The actuarial risk of developing toxicity and incidence of symptoms at fixed time points were not increased with a SIB. CONCLUSION: Performing a SIB did not increase genitourinary or rectal toxicity up to 8years' follow-up.
BACKGROUND AND PURPOSE: Local recurrences after radiotherapy are dose-dependent and occur in the dominant intraprostatic lesion (DIL). The purpose of this study was to evaluate the impact of a simultaneous integrated boost (SIB) to the magnetic resonance imaging (MRI)-defined DIL on toxicity. MATERIALS AND METHODS: Four-hundred and ten patients were treated with intensity-modulated radiotherapy. A median dose of 78Gy was prescribed to the prostate. A SIB of 82Gy to the DIL was performed in 225 patients (SIB+). Genitourinary and rectal toxicity on fixed time points up to 8years were compared between SIB- (185 patients) and SIB+ patients. Chi-square, Fisher's exact and Kaplan-Meier statistics were applied. With a median follow up of 72months, the six-year actuarial risk of genitourinary and rectal toxicity grade⩾2 was 31% and 12% respectively. The actuarial risk of developing toxicity and incidence of symptoms at fixed time points were not increased with a SIB. CONCLUSION: Performing a SIB did not increase genitourinary or rectal toxicity up to 8years' follow-up.
Authors: Almudena Zapatero; Maria Roch; Pablo Castro Tejero; David Büchser; Carmen Martin de Vidales; Saturnino González; Pablo Rodríguez; Luis Alberto San Jose; Guillermo Celada; Maria Teresa Murillo Journal: Br J Radiol Date: 2021-09-19 Impact factor: 3.039
Authors: E J Alexander; J R Murray; V A Morgan; S L Giles; S F Riches; S Hazell; K Thomas; S A Sohaib; A Thompson; A Gao; D P Dearnaley; N M DeSouza Journal: Radiother Oncol Date: 2019-09-05 Impact factor: 6.280