Miles Wischnewski1, Paul Zerr2, Dennis J L G Schutter2. 1. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands. Electronic address: m.wischnewski@donders.ru.nl. 2. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands.
Abstract
BACKGROUND: Theta oscillations in the electroencephalogram (EEG) are associated with learning and behavioral adaptation. OBJECTIVE: To investigate the effects of theta transcranial alternating current stimulation (tACS) applied to the frontal cortex on reversal learning. METHODS:Healthy volunteers participated in a sham-controlled between subjects design. TACS at 1 mA peak-to-peak was administered during a reward-punishment reversal learning task. Resting state EEG was measured before and after tACS and the task. RESULTS: Active tACS improved learning ability, but at the same time interfered with applying the rule to optimize behavior. Furthermore, a significant decrease in frontal theta-beta EEG ratios was observed following active tACS. CONCLUSIONS: Results provide behavioral and electrophysiological evidence for influencing reversal learning with exogenous oscillatory electric field potentials applied to the frontal cortex.
RCT Entities:
BACKGROUND: Theta oscillations in the electroencephalogram (EEG) are associated with learning and behavioral adaptation. OBJECTIVE: To investigate the effects of theta transcranial alternating current stimulation (tACS) applied to the frontal cortex on reversal learning. METHODS: Healthy volunteers participated in a sham-controlled between subjects design. TACS at 1 mA peak-to-peak was administered during a reward-punishment reversal learning task. Resting state EEG was measured before and after tACS and the task. RESULTS: Active tACS improved learning ability, but at the same time interfered with applying the rule to optimize behavior. Furthermore, a significant decrease in frontal theta-beta EEG ratios was observed following active tACS. CONCLUSIONS: Results provide behavioral and electrophysiological evidence for influencing reversal learning with exogenous oscillatory electric field potentials applied to the frontal cortex.
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