| Literature DB >> 27161804 |
Mauro Di Matteo1, Alessandra Ammazzalorso1, Federico Andreoli2, Irene Caffa3, Barbara De Filippis1, Marialuigia Fantacuzzi1, Letizia Giampietro1, Cristina Maccallini1, Alessio Nencioni3, Marco Daniele Parenti4, Debora Soncini3, Alberto Del Rio5, Rosa Amoroso1.
Abstract
The most frequently used treatment for hormone receptor positive breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC50 values that are similar to that of letrozole and SYN 20028567 were identified.Entities:
Keywords: Anticancer agents; Aromatase inhibitor; Imidazole; Sulfonamide; Synthesis
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Year: 2016 PMID： 27161804 DOI： 10.1016/j.bmcl.2016.04.078
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823