E Mutimura1, Q Shi2, D R Hoover3, K Anastos4, E Rudakemwa5, J C Dusingize6, J D Sinabye6, M T Yin7. 1. Regional Alliance for Sustainable Development (RASD), Kigali, Rwanda. eugene.mutimura@gmail.com. 2. New York Medical College, Valhalla, NY, USA. 3. The State University of New Jersey, New Brunswick, NJ, USA. 4. Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY, USA. 5. King Faisal Hospital Kigali, Kigali, Rwanda. 6. Regional Alliance for Sustainable Development (RASD), Kigali, Rwanda. 7. Columbia University Medical Center, New York, NY, USA.
Abstract
OBJECTIVES: The incidence of fractures appears to be increased in HIV-infected individuals. METHODS: We assessed bone quality using quantitative ultrasound (QUS) in HIV-infected and uninfected Rwandan women. A Sunlight Omnisense 7000 QUS was used to measure the speed of ultrasound (SOS) at the distal radius in 646 antiretroviral therapy (ART)-naïve HIV-infected women and 211 HIV-uninfected women. The Z-scores for SOS were based on data for women of the same age from the manufacturer's reference material. RESULTS: The mean CD4 cell count was 285 (± 166) cells/μL in the HIV-positive women. SOS Z-scores adjusted and unadjusted for body mass index did not differ between the groups. SOS did not differ by CD4 count (< 200 vs. ≥ 200 cells/μL: 4016 (± 117) vs. 4028 (± 107) m/s, respectively; p=0.19. CONCLUSIONS: In HIV-positive ART-naïve Rwandan women with advanced HIV disease, bone quality at the distal radius was similar to that in HIV-negative controls.
OBJECTIVES: The incidence of fractures appears to be increased in HIV-infected individuals. METHODS: We assessed bone quality using quantitative ultrasound (QUS) in HIV-infected and uninfected Rwandan women. A Sunlight Omnisense 7000 QUS was used to measure the speed of ultrasound (SOS) at the distal radius in 646 antiretroviral therapy (ART)-naïve HIV-infectedwomen and 211 HIV-uninfectedwomen. The Z-scores for SOS were based on data for women of the same age from the manufacturer's reference material. RESULTS: The mean CD4 cell count was 285 (± 166) cells/μL in the HIV-positive women. SOS Z-scores adjusted and unadjusted for body mass index did not differ between the groups. SOS did not differ by CD4 count (< 200 vs. ≥ 200 cells/μL: 4016 (± 117) vs. 4028 (± 107) m/s, respectively; p=0.19. CONCLUSIONS: In HIV-positive ART-naïve Rwandan women with advanced HIV disease, bone quality at the distal radius was similar to that in HIV-negative controls.
Authors: Sara E Dolan; Jeannie S Huang; Kathleen M Killilea; Meghan P Sullivan; Negar Aliabadi; Steven Grinspoon Journal: AIDS Date: 2004-02-20 Impact factor: 4.177
Authors: Julia H Arnsten; Ruth Freeman; Andrea A Howard; Michelle Floris-Moore; Nanette Santoro; Ellie E Schoenbaum Journal: Clin Infect Dis Date: 2006-02-24 Impact factor: 9.079
Authors: Andrew S Levey; Lesley A Stevens; Christopher H Schmid; Yaping Lucy Zhang; Alejandro F Castro; Harold I Feldman; John W Kusek; Paul Eggers; Frederick Van Lente; Tom Greene; Josef Coresh Journal: Ann Intern Med Date: 2009-05-05 Impact factor: 25.391
Authors: Michael T Yin; Michelle A Kendall; Xingye Wu; Katherine Tassiopoulos; Marc Hochberg; Jeannie S Huang; Marshall J Glesby; Hector Bolivar; Grace A McComsey Journal: AIDS Date: 2012-11-13 Impact factor: 4.177
Authors: Tewodros Rango Godebo; Marc Jeuland; Redda Tekle-Haimanot; Arti Shankar; Biniyam Alemayehu; Getachew Assefa; Gary Whitford; Amy Wolfe Journal: Bone Rep Date: 2019-12-07