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Literature DB >> 27161526

Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation.

Markus Klose¹, Laura Duvall¹, Weihua Li¹, Xitong Liang¹, Chi Ren¹, Joe Henry Steinbach², Paul H Taghert¹.

Abstract

The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness and does not require endogenous ligand (PDF) signaling or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness reflects the properties of the pacemaker cell type, not the receptor. Dopamine responsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large LNv. The activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms. Additionally, cell-autonomous PDF signaling reversed the circadian behavioral effects of lowered RalA activity. Thus, RalA activity confers high PDF responsiveness, providing a daily gate around the dawn hours to promote functional PDF signaling.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Drosophila; GPCR; PDF; RalA; circadian rhythms; dopamine

Mesh：

Substances：

Year: 2016 PMID： 27161526 PMCID： PMC4873338 DOI： 10.1016/j.neuron.2016.04.002

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

72 in total

1. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

Authors: S Nakashima; K Morinaka; S Koyama; M Ikeda; M Kishida; K Okawa; A Iwamatsu; S Kishida; A Kikuchi
Journal: EMBO J Date: 1999-07-01 Impact factor: 11.598

Review 2. Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis.

Authors: Gurpreet K Dhami; Stephen S G Ferguson
Journal: Pharmacol Ther Date: 2006-03-06 Impact factor: 12.310

Review 3. Endosomal generation of cAMP in GPCR signaling.

Authors: Jean-Pierre Vilardaga; Frederic G Jean-Alphonse; Thomas J Gardella
Journal: Nat Chem Biol Date: 2014-09 Impact factor: 15.040

4. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors.

Authors: Inge Mertens; Anick Vandingenen; Erik C Johnson; Orie T Shafer; W Li; J S Trigg; Arnold De Loof; Liliane Schoofs; Paul H Taghert
Journal: Neuron Date: 2005-10-20 Impact factor: 17.173

5. Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster.

Authors: R Andretic; J Hirsh
Journal: Proc Natl Acad Sci U S A Date: 2000-02-15 Impact factor: 11.205

6. Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms.

Authors: David Dahdal; David C Reeves; Marc Ruben; Myles H Akabas; Justin Blau
Journal: Neuron Date: 2010-12-09 Impact factor: 17.173

7. GW182 controls Drosophila circadian behavior and PDF-receptor signaling.

Authors: Yong Zhang; Patrick Emery
Journal: Neuron Date: 2013-04-10 Impact factor: 17.173

8. Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons.

Authors: Guan Cao; Michael N Nitabach
Journal: J Neurosci Date: 2008-06-18 Impact factor: 6.167

9. The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock.

Authors: Taishi Yoshii; Corinna Wülbeck; Hana Sehadova; Shobi Veleri; Dominik Bichler; Ralf Stanewsky; Charlotte Helfrich-Förster
Journal: J Neurosci Date: 2009-02-25 Impact factor: 6.167

10. The logic of circadian organization in Drosophila.

Authors: Stephane Dissel; Celia N Hansen; Özge Özkaya; Matthew Hemsley; Charalambos P Kyriacou; Ezio Rosato
Journal: Curr Biol Date: 2014-09-11 Impact factor: 10.834

22 in total

1. Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor in Drosophila melanogaster.

Authors: Esteban J Beckwith; Carlos E Hernando; Sofía Polcowñuk; Agustina P Bertolin; Estefania Mancini; M Fernanda Ceriani; Marcelo J Yanovsky
Journal: Genetics Date: 2017-08-11 Impact factor: 4.562

2. The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms.

Authors: Zepeng Yao; Amelia J Bennett; Jenna L Clem; Orie T Shafer
Journal: Cell Rep Date: 2016-12-13 Impact factor: 9.423

3. Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.

Authors: Dóra Nagy; Paola Cusumano; Gabriele Andreatta; Ane Martin Anduaga; Christiane Hermann-Luibl; Nils Reinhard; João Gesto; Christian Wegener; Gabriella Mazzotta; Ezio Rosato; Charalambos P Kyriacou; Charlotte Helfrich-Förster; Rodolfo Costa
Journal: PLoS Genet Date: 2019-06-13 Impact factor: 5.917

Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation.

1. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

Review 2. Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis.

Review 3. Endosomal generation of cAMP in GPCR signaling.

4. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors.

5. Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster.

6. Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms.

7. GW182 controls Drosophila circadian behavior and PDF-receptor signaling.

8. Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons.

9. The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock.

10. The logic of circadian organization in Drosophila.

1. Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor in Drosophila melanogaster.

2. The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms.

3. Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.

Review 4. Circadian Rhythms and Sleep in Drosophila melanogaster.

5. Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay.

6. Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila.

Review 7. Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.

8. Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila.

9. Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior.

Review 10. Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.