Haoyu Meng1, Peng Wu1, Yingming Zhao1, Zhihui Xu1, Ze-Mu Wang1, Chunjian Li1, Liansheng Wang1, Zhijian Yang2. 1. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 2. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: zhijianyangnj@njmu.edu.cn.
Abstract
OBJECTIVES: To investigate the association between pre-existing microalbuminuria among patients with preserved renal function and contrast- induced acute kidney injury (AKI) following coronary angiography. MATERIAL AND METHODS: 612 consecutive patients with preserved renal function (eGFR≥60ml/min and without macroalbuminuria) undergoing scheduled coronary angiography were stratified into microalbuminuria group (107 patients) and normal-albuminuria group (505 patients) according to the urine albumin to creatinine ratio (ACR) levels. Microalbuminuria was defined as ACR in the range of 30-300mg/g and normal-albuminuria was defined as ACR<30mg/g. Contrast-induced AKI was defined as a relative increase in serum creatinine (SCr) concentration of at least 25% or an absolute increase in SCr of 44.2μmol/L within 72h after the procedure. RESULTS: The peak increases of SCr in microalbuminuria group were larger than those in normal-albuminuria group (10.6±12.4μmol/L vs. 4.8±8.9μmol/L，P<0.001). The incidence of AKI was higher in patients with microalbuminuria than those with normal-albuminuria (12.1% vs. 5.0%, P=0.005). Multivariate analysis revealed that there was an association between microalbuminuria and contrast-induced AKI risk after adjusting for confounders. CONCLUSION: Pre-existing microalbuminuria is associated with greater risk for AKI in patients with a preserved renal function who undergo scheduled coronary angiography.
OBJECTIVES: To investigate the association between pre-existing microalbuminuria among patients with preserved renal function and contrast- induced acute kidney injury (AKI) following coronary angiography. MATERIAL AND METHODS: 612 consecutive patients with preserved renal function (eGFR≥60ml/min and without macroalbuminuria) undergoing scheduled coronary angiography were stratified into microalbuminuria group (107 patients) and normal-albuminuria group (505 patients) according to the urine albumin to creatinine ratio (ACR) levels. Microalbuminuria was defined as ACR in the range of 30-300mg/g and normal-albuminuria was defined as ACR<30mg/g. Contrast-induced AKI was defined as a relative increase in serum creatinine (SCr) concentration of at least 25% or an absolute increase in SCr of 44.2μmol/L within 72h after the procedure. RESULTS: The peak increases of SCr in microalbuminuria group were larger than those in normal-albuminuria group (10.6±12.4μmol/L vs. 4.8±8.9μmol/L，P<0.001). The incidence of AKI was higher in patients with microalbuminuria than those with normal-albuminuria (12.1% vs. 5.0%, P=0.005). Multivariate analysis revealed that there was an association between microalbuminuria and contrast-induced AKI risk after adjusting for confounders. CONCLUSION: Pre-existing microalbuminuria is associated with greater risk for AKI in patients with a preserved renal function who undergo scheduled coronary angiography.
Authors: Shu Min Tao; Xiang Kong; U Joseph Schoepf; Julian L Wichmann; Darby C Shuler; Chang Sheng Zhou; Guang Ming Lu; Long Jiang Zhang Journal: Eur Radiol Date: 2017-11-02 Impact factor: 5.315
Authors: Sheila M F Couto; Douglas I Machado; Carolina Conde; Vinicius C Silva; Adriana A Souza; Karina B Peres; Beatriz A Brandi; Maria De Fátima F Vattimo Journal: Biomed Res Int Date: 2020-11-17 Impact factor: 3.411