Literature DB >> 27160799

Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Daniël H van Raalte1, C Bruce Verchere2.   

Abstract

Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Glucagon-like peptide (GLP)-1 receptor agonists; beta-cell exhaustion; beta-cell protection; chronic treatment; insulin secretion

Mesh：

Substances：

Year:  2016        PMID： 27160799     DOI： 10.1016/j.tem.2016.04.009

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  7 in total

1.  Glucagon-like peptide-1 receptor agonist exendin-4 protects against interleukin-1β-mediated inhibition of glucose-stimulated insulin secretion by mouse insulinoma β cells.

Authors:  Ben Niu; Chao Li; Heng Su; Qingzhu Li; Qiu He; Lijuan Liu; Yuanming Xue; Tao Shen; Xueshan Xia
Journal:  Exp Ther Med       Date:  2017-07-19       Impact factor: 2.447

Review 2.  The dynamic plasticity of insulin production in β-cells.

Authors:  Brandon B Boland; Christopher J Rhodes; Joseph S Grimsby
Journal:  Mol Metab       Date:  2017-05-04       Impact factor: 7.422

3.  Long chain saturated and unsaturated fatty acids exert opposing effects on viability and function of GLP-1-producing cells: Mechanisms of lipotoxicity.

Authors:  Ketan Thombare; Stelia Ntika; Xuan Wang; Camilla Krizhanovskii
Journal:  PLoS One       Date:  2017-05-16       Impact factor: 3.240

Review 4.  The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into "Old" Diseases.

Authors:  Igor Alexander Harsch; Peter Christopher Konturek
Journal:  Med Sci (Basel)       Date:  2018-04-17

5.  Reducing Glucokinase Activity to Enhance Insulin Secretion: A Counterintuitive Theory to Preserve Cellular Function and Glucose Homeostasis.

Authors:  Nicholas B Whitticar; Craig S Nunemaker
Journal:  Front Endocrinol (Lausanne)       Date:  2020-06-09       Impact factor: 5.555

6.  Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography.

Authors:  Kate L White; Jitin Singla; Valentina Loconte; Jian-Hua Chen; Axel Ekman; Liping Sun; Xianjun Zhang; John Paul Francis; Angdi Li; Wen Lin; Kaylee Tseng; Gerry McDermott; Frank Alber; Andrej Sali; Carolyn Larabell; Raymond C Stevens
Journal:  Sci Adv       Date:  2020-12-09       Impact factor: 14.136

7.  Influence of Flavonoids on Mechanism of Modulation of Insulin Secretion.

Authors:  Juliana Mikaelly Dias Soares; Ana Ediléia Barbosa Pereira Leal; Juliane Cabral Silva; Jackson R G S Almeida; Helinando Pequeno de Oliveira
Journal:  Pharmacogn Mag       Date:  2017-11-13       Impact factor: 1.085
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.