Marcel Cerqueira César Machado1, Fabiano Pinheiro da Silva. 1. Faculdade de Medicina da Universidade de São Paulo, Laboratório de Emergências Clínicas (LIM-51), Av. Dr. Arnaldo, 455 sala 3189, CEP 01246-000, São Paulo - SP, Brazil. mccm37@uol.com.br.
Abstract
BACKGROUND: The intestinal barrier is a layer that constitutes the most important barrier against the external environment. It can be partially disrupted in several frequent scenarios, leading to autoimmune and inflammatory diseases. Translocation of intestinal luminal contents into the intestinal mucosa may induce inflammatory disorders and therefore tissue injuries. Disruption of the intestinal barrier may induce local and systemic injuries and may play a role in inflammatory bowel disease, liver diseases, the aging process and in the systemic inflammatory response syndrome, including lung, heart and brain dysfunctions. CONCLUSION: Here, we discuss how the maintenance of it selectively permeability is crucial to adequate absorption of nutrients, electrolytes and water while maintaining effective host defense properties in order to avoid intestinal injury, systemic inflammation and distant organ damage.
BACKGROUND: The intestinal barrier is a layer that constitutes the most important barrier against the external environment. It can be partially disrupted in several frequent scenarios, leading to autoimmune and inflammatory diseases. Translocation of intestinal luminal contents into the intestinal mucosa may induce inflammatory disorders and therefore tissue injuries. Disruption of the intestinal barrier may induce local and systemic injuries and may play a role in inflammatory bowel disease, liver diseases, the aging process and in the systemic inflammatory response syndrome, including lung, heart and brain dysfunctions. CONCLUSION: Here, we discuss how the maintenance of it selectively permeability is crucial to adequate absorption of nutrients, electrolytes and water while maintaining effective host defense properties in order to avoid intestinal injury, systemic inflammation and distant organ damage.
Authors: Elise L Ma; Allen D Smith; Neemesh Desai; Lumei Cheung; Marie Hanscom; Bogdan A Stoica; David J Loane; Terez Shea-Donohue; Alan I Faden Journal: Brain Behav Immun Date: 2017-07-01 Impact factor: 7.217
Authors: Anna M Salazar; Martin Resnik-Docampo; Matthew Ulgherait; Rebecca I Clark; Mimi Shirasu-Hiza; D Leanne Jones; David W Walker Journal: iScience Date: 2018-10-24