Literature DB >> 27160642

Synthesis and biological evaluation of novel lignan glycosides as anticancer agents.

Ying Wang1,2, Chao Xia1, Wei Zhang1, Yu Zhao3.   

Abstract

Novel lignan glycosides 1a-1 h as analogues of cleistanthin A were designed and synthesized. Most of these compounds displayed significant cytotoxicities against four cancer cell lines. Compound 1e displayed better cytotoxicity than cleistanthin A with IC50 values from 1.0 nm to 8.3 nm. Further lysosome acidity assay disclosed that 1e could totally inhibit the activity of V-ATPase at 60 nm.
© 2016 John Wiley & Sons A/S.

Entities:  

Keywords:  inhibitors; lignan glycosides; synthesis; vacuolar H + -ATPase

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Substances：

Year:  2016        PMID： 27160642     DOI： 10.1111/cbdd.12785

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  2 in total

1.  Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Authors:  John L Woodard; Andrew C Huntsman; Pratiq A Patel; Hee-Byung Chai; Ragu Kanagasabai; Soumendrakrishna Karmahapatra; Alexandria N Young; Yulin Ren; Malcolm S Cole; Denisse Herrera; Jack C Yalowich; A Douglas Kinghorn; Joanna E Burdette; James R Fuchs
Journal:  Bioorg Med Chem       Date:  2018-03-23       Impact factor: 3.641

2.  Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells.

Authors:  Haijiao Chen; Pengfei Liu; Ting Zhang; Yi Gao; Yingdi Zhang; Xiuyun Shen; Xiao Li; Weidong Shen
Journal:  Oncol Rep       Date:  2018-01-04       Impact factor: 3.906
  2 in total

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