Tolga Han Efe1, Tolga Cimen2, Ahmet Goktug Ertem3, Yusuf Coskun4, Murat Bilgin2, Haluk Furkan Sahan2, Hilal Erken Pamukcu2, Cagri Yayla3, Hamza Sunman2, Ilhami Yuksel4, Ekrem Yeter2. 1. Department of Cardiology, Diskapi Yildirim Beyazit Education and Training Hospital, Ankara, Turkey. medisay@gmail.com. 2. Department of Cardiology, Diskapi Yildirim Beyazit Education and Training Hospital, Ankara, Turkey. 3. Department of Cardiology, Turkiye Yuksek Ihtisas Education and Training Hospital, Ankara, Turkey. 4. Department of Gastroenterology, Diskapi Education and Training Hospital, Ankara, Turkey.
Abstract
BACKGROUND: There is much evidence linking inflammation to the initiation and continuation of atrial fibrillation (AF). Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic systemic inflammatory disorders. Atrial electromechanical delay (EMD) has been known as an early marker of AF. The objectives of this study were to evaluate the atrial electromechanical properties in patients with IBD. METHODS: Fifty-two patients with IBD and 26 healthy controls were recruited in the study. Twenty-five of patients with IBD were on active period, and the remaining 27 were on remission period. Atrial electromechanical properties were measured by using transthoracic echocardiography and tissue Doppler imaging and simultaneous surface ECG recording. Interatrial EMD, left intraatrial EMD, and right intraatrial EMD were calculated. RESULTS: Patients on activation with IBD had significantly prolonged left and right intraatrial EMDs and interatrial EMD compared to patients on remission (P = 0.048, P = 0.036, P < 0.001, respectively) and healthy controls (P < 0.001, for all comparisons). Left and right intraatrial EMDs and interatrial EMD were also found to be higher when patients on remission with IBD compared with healthy controls. No statistical difference was observed between UC and CD in terms of inter- and intraatrial EMDs. CONCLUSIONS: Atrial electromechanical conduction is prolonged in IBD, and exposure to chronic inflammation may lead to structural and electrophysiological changes in the atrial tissue that causes slow conduction. Measurement of atrial EMD parameters might be used to predict the risk for the development of AF in patients with IBD.
BACKGROUND: There is much evidence linking inflammation to the initiation and continuation of atrial fibrillation (AF). Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic systemic inflammatory disorders. Atrial electromechanical delay (EMD) has been known as an early marker of AF. The objectives of this study were to evaluate the atrial electromechanical properties in patients with IBD. METHODS: Fifty-two patients with IBD and 26 healthy controls were recruited in the study. Twenty-five of patients with IBD were on active period, and the remaining 27 were on remission period. Atrial electromechanical properties were measured by using transthoracic echocardiography and tissue Doppler imaging and simultaneous surface ECG recording. Interatrial EMD, left intraatrial EMD, and right intraatrial EMD were calculated. RESULTS:Patients on activation with IBD had significantly prolonged left and right intraatrial EMDs and interatrial EMD compared to patients on remission (P = 0.048, P = 0.036, P < 0.001, respectively) and healthy controls (P < 0.001, for all comparisons). Left and right intraatrial EMDs and interatrial EMD were also found to be higher when patients on remission with IBD compared with healthy controls. No statistical difference was observed between UC and CD in terms of inter- and intraatrial EMDs. CONCLUSIONS: Atrial electromechanical conduction is prolonged in IBD, and exposure to chronic inflammation may lead to structural and electrophysiological changes in the atrial tissue that causes slow conduction. Measurement of atrial EMD parameters might be used to predict the risk for the development of AF in patients with IBD.
Authors: Kai O Hensel; Francisca E Abellan Schneyder; Lucia Wilke; Andreas Heusch; Stefan Wirth; Andreas C Jenke Journal: Sci Rep Date: 2017-06-07 Impact factor: 4.379
Authors: Güray Can; Nergis Ekmen; Hatice Can; Muhammet Fatih Bayraktar; Muhammed Emin Demirkol; Meral Akdoğan Kayhan; Hadi Sasani Journal: Saudi J Gastroenterol Date: 2021 Sep-Oct Impact factor: 2.485