Literature DB >> 27158288

Investigation of particle inertial migration in high particle concentration suspension flow by multi-electrodes sensing and Eulerian-Lagrangian simulation in a square microchannel.

Tong Zhao, Jiafeng Yao1, Kai Liu2, Masahiro Takei1.   

Abstract

The inertial migration of neutrally buoyant spherical particles in high particle concentration (αpi  > 3%) suspension flow in a square microchannel was investigated by means of the multi-electrodes sensing method which broke through the limitation of conventional optical measurement techniques in the high particle concentration suspensions due to interference from the large particle numbers. Based on the measured particle concentrations near the wall and at the corner of the square microchannel, particle cross-sectional migration ratios are calculated to quantitatively estimate the migration degree. As a result, particle migration to four stable equilibrium positions near the centre of each face of the square microchannel is found only in the cases of low initial particle concentration up to 5.0 v/v%, while the migration phenomenon becomes partial as the initial particle concentration achieves 10.0 v/v% and disappears in the cases of the initial particle concentration αpi  ≥ 15%. In order to clarify the influential mechanism of particle-particle interaction on particle migration, an Eulerian-Lagrangian numerical model was proposed by employing the Lennard-Jones potential as the inter-particle potential, while the inertial lift coefficient is calculated by a pre-processed semi-analytical simulation. Moreover, based on the experimental and simulation results, a dimensionless number named migration index was proposed to evaluate the influence of the initial particle concentration on the particle migration phenomenon. The migration index less than 0.1 is found to denote obvious particle inertial migration, while a larger migration index denotes the absence of it. This index is helpful for estimation of the maximum initial particle concentration for the design of inertial microfluidic devices.

Year:  2016        PMID: 27158288      PMCID: PMC4833750          DOI: 10.1063/1.4946012

Source DB:  PubMed          Journal:  Biomicrofluidics        ISSN: 1932-1058            Impact factor:   2.800


  20 in total

Review 1.  Suspension flow in microfluidic devices--a review of experimental techniques focussing on concentration and velocity gradients.

Authors:  A M C van Dinther; C G P H Schroën; F J Vergeldt; R G M van der Sman; R M Boom
Journal:  Adv Colloid Interface Sci       Date:  2012-02-23       Impact factor: 12.984

2.  Sheathless inertial cell ordering for extreme throughput flow cytometry.

Authors:  Soojung Claire Hur; Henry Tat Kwong Tse; Dino Di Carlo
Journal:  Lab Chip       Date:  2009-12-18       Impact factor: 6.799

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Authors:  Igor Cima; Chay Wen Yee; Florina S Iliescu; Wai Min Phyo; Kiat Hon Lim; Ciprian Iliescu; Min Han Tan
Journal:  Biomicrofluidics       Date:  2013-01-24       Impact factor: 2.800

4.  Three dimensional, sheathless, and high-throughput microparticle inertial focusing through geometry-induced secondary flows.

Authors:  Aram J Chung; Daniel R Gossett; Dino Di Carlo
Journal:  Small       Date:  2012-11-12       Impact factor: 13.281

5.  Double spiral microchannel for label-free tumor cell separation and enrichment.

Authors:  Jiashu Sun; Mengmeng Li; Chao Liu; Yi Zhang; Dingbin Liu; Wenwen Liu; Guoqing Hu; Xingyu Jiang
Journal:  Lab Chip       Date:  2012-10-21       Impact factor: 6.799

6.  Continuous separation of blood cells in spiral microfluidic devices.

Authors:  Nivedita Nivedita; Ian Papautsky
Journal:  Biomicrofluidics       Date:  2013-09-05       Impact factor: 2.800

7.  High-throughput inertial particle focusing in a curved microchannel: Insights into the flow-rate regulation mechanism and process model.

Authors:  Nan Xiang; Hong Yi; Ke Chen; Dongke Sun; Di Jiang; Qing Dai; Zhonghua Ni
Journal:  Biomicrofluidics       Date:  2013-08-08       Impact factor: 2.800

8.  Development of three-dimensional integrated microchannel-electrode system to understand the particles' movement with electrokinetics.

Authors:  J Yao; H Obara; A Sapkota; M Takei
Journal:  Biomicrofluidics       Date:  2016-03-15       Impact factor: 2.800

9.  Inertial migration of cancer cells in blood flow in microchannels.

Authors:  Tatsuya Tanaka; Takuji Ishikawa; Keiko Numayama-Tsuruta; Yohsuke Imai; Hironori Ueno; Takefumi Yoshimoto; Noriaki Matsuki; Takami Yamaguchi
Journal:  Biomed Microdevices       Date:  2012-02       Impact factor: 2.838

10.  Size-selective collection of circulating tumor cells using Vortex technology.

Authors:  Elodie Sollier; Derek E Go; James Che; Daniel R Gossett; Sean O'Byrne; Westbrook M Weaver; Nicolas Kummer; Matthew Rettig; Jonathan Goldman; Nicholas Nickols; Susan McCloskey; Rajan P Kulkarni; Dino Di Carlo
Journal:  Lab Chip       Date:  2013-09-23       Impact factor: 6.799

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