Anupam Mishra1, Monica Sachadeva2, Ankita Jain2, Nimisha Mishra Shukla3, Amita Pandey4. 1. Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow. Electronic address: amishra_ent@yahoo.com. 2. Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow. 3. Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow; John Muir Hospital, Walnut Creek, CA, USA. 4. Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow; Department of Medical Genetics / Obstetrics and Gynaecology, King George Medical University, Lucknow, India.
Abstract
BACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) has witnessed a four-fold increase in the incidence at our facility in the current decade as compared to the 1980s. With high global incidence of human pappilloma virus (HPV) related oropharyngeal cancer in India, we hypothesize its implication in JNA as it has not yet been reported. METHODS: Clinico-Surgical variables of 6 patients of JNA were included for correlation and their tissue samples were subjected to western blotting (WB), polymerase chain reaction and immunoflorescence to demonstrate a definite association with HPV. In addition 6 control samples (adenoids) underwent WB analysis. OBSERVATIONS: A universal presence of HPV with JNA is novel 'discovery' and has suggested a possibility of a definite association. Only a single case suggested weak infection. None of the controls suggested infection, thus ruling out the presence of HPV in nasopharynx of normal population. INTERPRETATION: With the dawn of this definite association, no specific conclusions can yet be drawn but a whole plethora of questions have emerged with our novel 'discovery'.
BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) has witnessed a four-fold increase in the incidence at our facility in the current decade as compared to the 1980s. With high global incidence of humanpappilloma virus (HPV) related oropharyngeal cancer in India, we hypothesize its implication in JNA as it has not yet been reported. METHODS: Clinico-Surgical variables of 6 patients of JNA were included for correlation and their tissue samples were subjected to western blotting (WB), polymerase chain reaction and immunoflorescence to demonstrate a definite association with HPV. In addition 6 control samples (adenoids) underwent WB analysis. OBSERVATIONS: A universal presence of HPV with JNA is novel 'discovery' and has suggested a possibility of a definite association. Only a single case suggested weak infection. None of the controls suggested infection, thus ruling out the presence of HPV in nasopharynx of normal population. INTERPRETATION: With the dawn of this definite association, no specific conclusions can yet be drawn but a whole plethora of questions have emerged with our novel 'discovery'.
Authors: Amy Dickinson; Man Xu; Suvi Silén; Yilin Wang; Yu Fu; Mohammadreza Sadeghi; Mari Toppinen; Timo Carpén; Klaus Hedman; Antti Mäkitie; Maria Söderlund-Venermo Journal: Eur Arch Otorhinolaryngol Date: 2018-12-21 Impact factor: 2.503