Literature DB >> 2715797

Computer simulation of the conformational behavior of cholecystokinin fragments: conformational families of sulfated CCK8.

M Kreissler1, M Pesquer, B Maigret, M C Fournié-Zaluski, B P Roques.   

Abstract

Display methods, such as principal component analysis, and clustering methods were applied to a sample of cholecystokinin, (sulfated CCK8) conformations obtained from a Monte Carlo simulation. It is shown that six families of conformations can entirely describe the sample. Each family represents a typical conformer. These theoretical models are in agreement with recent experimental results which stress the predominance of folded conformers in aqueous medium.

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Year:  1989        PMID： 2715797     DOI： 10.1007/BF01590997

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN： 0920-654X            Impact factor:   3.686


  9 in total

1.  Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.

Authors:  P Robberecht; M Deschodt-Lanckman; J J Vanderhaeghen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

2.  Monte Carlo-minimization approach to the multiple-minima problem in protein folding.

Authors:  Z Li; H A Scheraga
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

3.  The importance of the amino acid in position 27 of cholecystokinin in determining its biological activity on pancreatic acini.

Authors:  J D Gardner; M D Walker; J Martinez; G P Priestly; S Natarajan; M Bodanszky
Journal:  Biochim Biophys Acta       Date:  1980-07-03

4.  Peptide-monoamine coexistence: studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons.

Authors:  L R Skirboll; A A Grace; D W Hommer; J Rehfeld; M Goldstein; T Hökfelt; B S Bunney
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

5.  Tritium-sensitive film autoradiography of [3H]cholecystokinin-5/pentagastrin receptors in rat brain.

Authors:  P Gaudreau; R Quirion; S St-Pierre; C B Pert
Journal:  Eur J Pharmacol       Date:  1983-01-28       Impact factor: 4.432

6.  Prediction of the native conformation of a polypeptide by a statistical-mechanical procedure. I. Backbone structure of enkephalin.

Authors:  G H Paine; H A Scheraga
Journal:  Biopolymers       Date:  1985-08       Impact factor: 2.505

7.  Conformational analysis of cholecystokinin CCK26-33 and related fragments by 1H NMR spectroscopy, fluorescence-transfer measurements, and calculations.

Authors:  M C Fournié-Zaluski; J Belleney; B Lux; C Durieux; D Gérard; G Gacel; B Maigret; B P Roques
Journal:  Biochemistry       Date:  1986-07-01       Impact factor: 3.162

8.  1H NMR conformational study of sulfated and non-sulfated cholecystokinin fragment CCK27-33: influence of the sulfate group on the peptide folding.

Authors:  C Durieux; J Belleney; J Y Lallemand; B P Roques; M C Fournie-Zaluski
Journal:  Biochem Biophys Res Commun       Date:  1983-07-29       Impact factor: 3.575

9.  Models for the conformational behaviour of angiotensin-II in acidic aqueous solutions.

Authors:  C Marchionini; B Maigret; S Prémilat
Journal:  Biochem Biophys Res Commun       Date:  1983-04-15       Impact factor: 3.575
  9 in total
  2 in total

1.  Computational simulations of the conformational behaviour of the adhesive proteins RGDS fragment.

Authors:  M Cotrait; M Kreissler; J Hoflack; J M Lehn; B Maigret
Journal:  J Comput Aided Mol Des       Date:  1992-04       Impact factor: 3.686

2.  Computer simulation of the conformational behaviour of angiotensinogen (6-13) renin substrate.

Authors:  M Benkoulouche; M Cotrait; B Maigret
Journal:  J Comput Aided Mol Des       Date:  1992-02       Impact factor: 3.686
  2 in total

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