Applications of PET/CT in Pediatric Patients with Fever of Unknown Origin.

Fever of unknown origin (FUO) is a challenging problem. In children, FUO is critical, as it may hide a life threatening disease. One of the main difficulties in managing patients with FUO is the absence of a universal diagnostic approach. There are many impending causes for FUO. Most cases are attributable to atypical presentations of common diseases. The key to establishing the diagnosis is through comprehensive clinical data and targeted investigations. Despite all efforts, the underlying cause remains undiagnosed in many cases. PET/CT is a powerful modality that has been proven to be useful in many common causes that could emerge as FUO. This article reviews the utility of PET/CT imaging in children with FUO.