| Literature DB >> 27156772 |
Yuan Sun1, Aileen Shieh1, Se Hye Kim1, Samantha King1, Anne Kim1, Hui-Lung Sun2, Carlo M Croce2, Jon R Parquette1.
Abstract
A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against cancer cell lines A549, NCI-H460 and NCI-H23. The release of active camptothecin was highly dependent on conjugate concentration, temperature and pH of the solution.Entities:
Keywords: Cytotoxicity; Drug delivery; Nanoparticle; Nanotube; Self-assembly
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Year: 2016 PMID： 27156772 DOI： 10.1016/j.bmcl.2016.04.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823