Literature DB >> 27156049

Production and in vivo imaging of (203)Pb as a surrogate isotope for in vivo (212)Pb internal absorbed dose studies.

Domokos Máthé1, Krisztián Szigeti2, Nikolett Hegedűs3, Ildikó Horváth4, Dániel S Veres5, Béla Kovács6, Zoltán Szűcs7.   

Abstract

(212)Pb is a clinically relevant therapeutic alpha emitter isotope. A surrogate, (203)Pb, if prepared with sufficiently high specific activity could be used to estimate (212)Pb in vivo absorbed doses. An improved production procedure of (203)Pb with a simple, new separation method and high specific radioactivity for imaging is reported. We determined the in-vivo biodistribution of (203)Pb in mice by SPECT/CT. This highlights application possibilities of (203)Pb for further in vivo and clinical uses (radiolabeled (212)Pb-peptide co-injection, dosimetry calculation).
Copyright © 2016. Published by Elsevier Ltd.

Entities:  

Keywords:  (203)Pb; (212)Pb; Gamma-emitting isotope; NanoSPECT/CT; Targeted alpha therapy

Mesh：

Substances：

Year:  2016        PMID： 27156049     DOI： 10.1016/j.apradiso.2016.04.015

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  5 in total

1.  Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting.

Authors:  Jianquan Yang; Jingli Xu; Lina Cheuy; Rene Gonzalez; Darrell R Fisher; Yubin Miao
Journal:  Mol Pharm       Date:  2019-02-25       Impact factor: 4.939

2.  Development of clinical simultaneous SPECT/MRI.

Authors:  Brian F Hutton; Michele Occhipinti; Andre Kuehne; Domokos Máthé; Noémi Kovács; Helmar Waiczies; Kjell Erlandsson; Debora Salvado; Marco Carminati; Giovanni L Montagnani; Susan C Short; Luisa Ottobrini; Pieter van Mullekom; Claudio Piemonte; Tamas Bukki; Zoltan Nyitrai; Zoltan Papp; Kalman Nagy; Thoralf Niendorf; Irene de Francesco; Carlo Fiorini
Journal:  Br J Radiol       Date:  2017-03-07       Impact factor: 3.039

Review 3.  Progress in Targeted Alpha-Particle Therapy. What We Learned about Recoils Release from In Vivo Generators.

Authors:  Ján Kozempel; Olga Mokhodoeva; Martin Vlk
Journal:  Molecules       Date:  2018-03-05       Impact factor: 4.411

4.  Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair.

Authors:  Brooke L McNeil; Andrew K H Robertson; Winnie Fu; Hua Yang; Cornelia Hoehr; Caterina F Ramogida; Paul Schaffer
Journal:  EJNMMI Radiopharm Chem       Date:  2021-02-01

5.  Quantitative SPECT/CT imaging of lead-212: a phantom study.

Authors:  Monika Kvassheim; Mona-Elisabeth R Revheim; Caroline Stokke
Journal:  EJNMMI Phys       Date:  2022-08-04
  5 in total

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