Literature DB >> 27156008

Sevoflurane-induced pica in female rats.

Kouichi Yamamoto1, Emiri Yamamoto2, Toru Sugimoto3, Takuya Sagakami3, Atsushi Yamatodani4.   

Abstract

We examined the effects of volatile anesthetics on pica, which can be used to assess nausea and vomiting in rats. We found that inhalation anesthesia with sevoflurane significantly induced pica in female but not male rats. Among the female rats, young rats (8 weeks old) were more susceptible to its induction than adult rats (20 weeks old) with ovariectomy or sham-surgery. Anti-emetic drugs that are used to prevent postoperative nausea and vomiting (PONV) inhibited the pica. These results suggest that sevoflurane-induced pica in young female rats has the potential to be an animal model of PONV in humans.
Copyright © 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Anti-emetic drugs; Pica; Postoperative nausea and vomiting

Mesh：

Substances：

Year:  2016        PMID： 27156008     DOI： 10.1016/j.jphs.2016.03.015

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  3 in total

1.  Isoflurane induces c-Fos expression in the area postrema of the rat.

Authors:  Tetsutaro Hase; Toshikazu Hashimoto; Hitoshi Saito; Yosuke Uchida; Rui Kato; Kenkichi Tsuruga; Koichi Takita; Yuji Morimoto
Journal:  J Anesth       Date:  2019-07-17       Impact factor: 2.078

2.  Detection of Nausea-Like Response in Rats by Monitoring Facial Expression.

Authors:  Kouichi Yamamoto; Soichi Tatsutani; Takayuki Ishida
Journal:  Front Pharmacol       Date:  2017-01-10       Impact factor: 5.810

3.  Association of nausea with buprenorphine analgesia for rats.

Authors:  R Sarabia-Estrada; A Cowan; B M Tyler; M Guarnieri
Journal:  Lab Anim (NY)       Date:  2017-05-22       Impact factor: 12.625
  3 in total

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