| Literature DB >> 27155817 |
Yong-Tao Xiao1, Wei-Hui Yan2, Yi Cao3, Jun-Kai Yan4, Wei Cai5.
Abstract
The cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) have been implicated as important mediators of the inflammatory reaction in patients with intestinal inflammation. The present study was designed to investigate the roles of these cytokines on mucosal barrier function in a mouse model of acute colitis with using anti-cytokine strategies. Mice received 3% dextran sulfate sodium (DSS) in their drinking water for 7days showed morphological alteration of mucosa and increase of intestinal permeability. Administration of IL-6 monoclonal antibody (mAb) or TNF-α mAb significantly attenuated intestinal permeability. IL-6 mAb and TNF-α mAb treatment also effectively suppressed the expression of claudin-2 and myosin light chain kinase (MLCK). Taken together, we indicated that anti-IL-6 and anti-TNF-α therapy prevent intestinal permeability induced by intestinal inflammation.Entities:
Keywords: Claudin-2; Dextran sulfate sodium; IL-6; MLCK; TNF-α
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Year: 2016 PMID： 27155817 DOI： 10.1016/j.cyto.2016.04.012
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861