| Literature DB >> 27155521 |
Abstract
The family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3). All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member of the JADE family, JADE1. Studies addressing the biochemical, cellular and biological role of JADE1 are discussed. Recent discoveries of JADE1 function in the regulation of the epithelial cell cycle with potential relevance to disease are presented. Unresolved questions and future directions are formulated.Entities:
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Year: 2016 PMID: 27155521 PMCID: PMC4903948 DOI: 10.1016/j.gene.2016.05.002
Source DB: PubMed Journal: Gene ISSN: 0378-1119 Impact factor: 3.688