The Challenge of Clostridium difficile Infection.

Clostridium difficile infection is a major problem in the United States, resulting in significant morbidity, mortality, and financial costs to the health care system. This commentary provides an update regarding the epidemiology, diagnosis, current recommended management, and challenges surrounding C. difficile infection. ©2016 by the North Carolina Institute of Medicine and The Duke Endowment. All rights reserved.