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Literature DB >> 27154323

The role of cGAS in innate immunity and beyond.

Abstract

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyond infection, accumulating evidence indicates that cGAS is also active during autoimmune diseases and controls immune responses that underlie cancer immunosurveillance. In this review, we highlight our current understanding of DNA sensing by cGAS and its involvement in human disease.

Entities: Chemical

Keywords: DNA sensing; Innate immunity; Type I interferons

Mesh：

Substances：

Year: 2016 PMID： 27154323 DOI： 10.1007/s00109-016-1423-2

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 5.606

70 in total

1. Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells.

Authors: Yu J Shen; Nina Le Bert; Anuja A Chitre; Christine Xing'Er Koo; Xing H Nga; Samantha S W Ho; Muznah Khatoo; Nikki Y Tan; Ken J Ishii; Stephan Gasser
Journal: Cell Rep Date: 2015-04-09 Impact factor: 9.423

2. Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.

Authors: Takayuki Abe; Glen N Barber
Journal: J Virol Date: 2014-03-05 Impact factor: 5.103

3. Activation of the STING adaptor attenuates experimental autoimmune encephalitis.

Authors: Henrique Lemos; Lei Huang; Phillip R Chandler; Eslam Mohamed; Guilherme R Souza; Lingqian Li; Gabriela Pacholczyk; Glen N Barber; Yoshihiro Hayakawa; David H Munn; Andrew L Mellor
Journal: J Immunol Date: 2014-05-05 Impact factor: 5.422

4. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Authors: Philip J Kranzusch; Amy Si-Ying Lee; James M Berger; Jennifer A Doudna
Journal: Cell Rep Date: 2013-05-23 Impact factor: 9.423

5. Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.

Authors: Elizabeth E Gray; Piper M Treuting; Joshua J Woodward; Daniel B Stetson
Journal: J Immunol Date: 2015-07-29 Impact factor: 5.422

6. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Authors: Anna-Maria Herzner; Cristina Amparo Hagmann; Marion Goldeck; Steven Wolter; Kirsten Kübler; Sabine Wittmann; Thomas Gramberg; Liudmila Andreeva; Karl-Peter Hopfner; Christina Mertens; Thomas Zillinger; Tengchuan Jin; Tsan Sam Xiao; Eva Bartok; Christoph Coch; Damian Ackermann; Veit Hornung; Janos Ludwig; Winfried Barchet; Gunther Hartmann; Martin Schlee
Journal: Nat Immunol Date: 2015-09-07 Impact factor: 25.606

7. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Authors: Anthony Rongvaux; Ruaidhrí Jackson; Christian C D Harman; Tuo Li; A Phillip West; Marcel R de Zoete; Youtong Wu; Brian Yordy; Saquib A Lakhani; Chia-Yi Kuan; Tadatsugu Taniguchi; Gerald S Shadel; Zhijian J Chen; Akiko Iwasaki; Richard A Flavell
Journal: Cell Date: 2014-12-18 Impact factor: 41.582

8. A diverse range of gene products are effectors of the type I interferon antiviral response.

Authors: John W Schoggins; Sam J Wilson; Maryline Panis; Mary Y Murphy; Christopher T Jones; Paul Bieniasz; Charles M Rice
Journal: Nature Date: 2011-04-10 Impact factor: 49.962

9. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.

Authors: Vladislav Pokatayev; Naushaba Hasin; Hyongi Chon; Susana M Cerritelli; Kiran Sakhuja; Jerrold M Ward; H Douglas Morris; Nan Yan; Robert J Crouch
Journal: J Exp Med Date: 2016-02-15 Impact factor: 14.307

Review 10. STING: infection, inflammation and cancer.

Authors: Glen N Barber
Journal: Nat Rev Immunol Date: 2015-12 Impact factor: 53.106

15 in total

1. Nucleic acid-mediated autoinflammation and autoimmunity-type I interferonopathies.

Authors: Min Ae Lee-Kirsch; Claudia Günther; Axel Roers
Journal: J Mol Med (Berl) Date: 2016-10 Impact factor: 4.599

2. cGAS is essential for the antitumor effect of immune checkpoint blockade.

Authors: Hua Wang; Shuiqing Hu; Xiang Chen; Heping Shi; Chuo Chen; Lijun Sun; Zhijian J Chen
Journal: Proc Natl Acad Sci U S A Date: 2017-01-30 Impact factor: 11.205

Review 3. The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response.

Authors: Jenna M Antonucci; Corine St Gelais; Li Wu
Journal: Front Immunol Date: 2017-11-10 Impact factor: 7.561

4. Signalling strength determines proapoptotic functions of STING.

Authors: Muhammet F Gulen; Ute Koch; Simone M Haag; Fabian Schuler; Lionel Apetoh; Andreas Villunger; Freddy Radtke; Andrea Ablasser
Journal: Nat Commun Date: 2017-09-05 Impact factor: 14.919

5. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Authors: Selene Glück; Baptiste Guey; Muhammet Fatih Gulen; Katharina Wolter; Tae-Won Kang; Niklas Arndt Schmacke; Anne Bridgeman; Jan Rehwinkel; Lars Zender; Andrea Ablasser
Journal: Nat Cell Biol Date: 2017-07-31 Impact factor: 28.824

6. cGAS surveillance of micronuclei links genome instability to innate immunity.

Authors: Karen J Mackenzie; Paula Carroll; Carol-Anne Martin; Olga Murina; Adeline Fluteau; Daniel J Simpson; Nelly Olova; Hannah Sutcliffe; Jacqueline K Rainger; Andrea Leitch; Ruby T Osborn; Ann P Wheeler; Marcin Nowotny; Nick Gilbert; Tamir Chandra; Martin A M Reijns; Andrew P Jackson
Journal: Nature Date: 2017-07-24 Impact factor: 49.962