Erney Ramírez-Aportela1, José Ramón López-Blanco2, Pablo Chacón2. 1. Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute C.S.I.C, Madrid 28006, Spain Centro de Investigaciones Biológicas, CSIC, Madrid E-28040, Spain. 2. Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute C.S.I.C, Madrid 28006, Spain.
Abstract
UNLABELLED: The prediction of protein-protein complexes from the structures of unbound components is a challenging and powerful strategy to decipher the mechanism of many essential biological processes. We present a user-friendly protein-protein docking server based on an improved version of FRODOCK that includes a complementary knowledge-based potential. The web interface provides a very effective tool to explore and select protein-protein models and interactively screen them against experimental distance constraints. The competitive success rates and efficiency achieved allow the retrieval of reliable potential protein-protein binding conformations that can be further refined with more computationally demanding strategies. AVAILABILITY AND IMPLEMENTATION: The server is free and open to all users with no login requirement at http://frodock.chaconlab.org CONTACT: pablo@chaconlab.org SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
UNLABELLED: The prediction of protein-protein complexes from the structures of unbound components is a challenging and powerful strategy to decipher the mechanism of many essential biological processes. We present a user-friendly protein-protein docking server based on an improved version of FRODOCK that includes a complementary knowledge-based potential. The web interface provides a very effective tool to explore and select protein-protein models and interactively screen them against experimental distance constraints. The competitive success rates and efficiency achieved allow the retrieval of reliable potential protein-protein binding conformations that can be further refined with more computationally demanding strategies. AVAILABILITY AND IMPLEMENTATION: The server is free and open to all users with no login requirement at http://frodock.chaconlab.org CONTACT: pablo@chaconlab.org SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: Rubén M Buey; David Fernández-Justel; José M de Pereda; José L Revuelta; Peter Schürmann; Bob B Buchanan; Monica Balsera Journal: Proc Natl Acad Sci U S A Date: 2018-12-03 Impact factor: 11.205
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