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Literature DB >> 27153530

METTL3 Gains R/W Access to the Epitranscriptome.

Ulrike Schumann¹, Andrew Shafik¹, Thomas Preiss².

Abstract

Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.

Entities: Chemical Gene

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Year: 2016 PMID： 27153530 DOI： 10.1016/j.molcel.2016.04.024

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

20 in total

1. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings.

Authors: Marlene Reichel; Yalin Liao; Mandy Rettel; Chikako Ragan; Maurits Evers; Anne-Marie Alleaume; Rastislav Horos; Matthias W Hentze; Thomas Preiss; Anthony A Millar
Journal: Plant Cell Date: 2016-10-11 Impact factor: 11.277

2. Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.

Authors: Can-Ming Li; Ming Li; Wen-Bo Zhao; Zeng-Chun Ye; Hui Peng
Journal: Front Mol Biosci Date: 2021-07-09

Review 3. The role of m⁶A RNA methylation in human cancer.

Authors: Xiao-Yu Chen; Jing Zhang; Jin-Shui Zhu
Journal: Mol Cancer Date: 2019-05-29 Impact factor: 27.401

Review 4. Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy.

Authors: Yuanjun Lu; Yau-Tuen Chan; Hor-Yue Tan; Sha Li; Ning Wang; Yibin Feng
Journal: Mol Cancer Date: 2020-04-27 Impact factor: 27.401

5. Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors.

Authors: Kai Li; Haiqing Luo; Hui Luo; Xiao Zhu
Journal: Aging (Albany NY) Date: 2020-11-20 Impact factor: 5.682

METTL3 Gains R/W Access to the Epitranscriptome.

1. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings.

2. Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.

Review 3. The role of m⁶A RNA methylation in human cancer.

Review 4. Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy.

5. Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors.

Review 6. Novel insights into the m⁶A-RNA methyltransferase METTL3 in cancer.

7. The m⁶A-related gene signature for predicting the prognosis of breast cancer.

Review 8. Function and clinical significance of N6-methyladenosine in digestive system tumours.

Review 9. Novel insights into the interplay between m⁶A modification and noncoding RNAs in cancer.

10. Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma.

METTL3 Gains R/W Access to the Epitranscriptome.

1. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings.

2. Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.

Review 3. The role of m6A RNA methylation in human cancer.

Review 4. Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy.

5. Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors.

Review 6. Novel insights into the m6A-RNA methyltransferase METTL3 in cancer.

7. The m6A-related gene signature for predicting the prognosis of breast cancer.

Review 8. Function and clinical significance of N6-methyladenosine in digestive system tumours.

Review 9. Novel insights into the interplay between m6A modification and noncoding RNAs in cancer.

10. Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma.

Review 3. The role of m⁶A RNA methylation in human cancer.

Review 6. Novel insights into the m⁶A-RNA methyltransferase METTL3 in cancer.

7. The m⁶A-related gene signature for predicting the prognosis of breast cancer.

Review 9. Novel insights into the interplay between m⁶A modification and noncoding RNAs in cancer.