Literature DB >> 27153298

"One-Pot" Approach to 8-Acylated 2-Quinolinones via Palladium-Catalyzed Regioselective Acylation of Quinoline N-Oxides.

Xiaopei Chen1, Xiuling Cui1,2, Yangjie Wu1.   

Abstract

A "one-pot" facile and efficient protocol for 8-acylated 2-quinolinones has been developed through palladium-catalyzed acylation of quinoline N-oxides, which proceeds with high selectivity at the C8-position. The desired products were isolated in up to 95% yield and good functional group tolerance. A palladacycle was isolated from the catalytic process and proposed as a key intermediate.

Entities:  

Year:  2016        PMID： 27153298     DOI： 10.1021/acs.orglett.6b00923

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

Review 1.  A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.

Authors:  Carlo Sambiagio; David Schönbauer; Remi Blieck; Toan Dao-Huy; Gerit Pototschnig; Patricia Schaaf; Thomas Wiesinger; Muhammad Farooq Zia; Joanna Wencel-Delord; Tatiana Besset; Bert U W Maes; Michael Schnürch
Journal:  Chem Soc Rev       Date:  2018-08-28       Impact factor: 54.564

2.  Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones.

Authors:  Xiaochen Du; Jianjun Huang; Anton A Nechaev; Ruwei Yao; Jing Gong; Erik V Van der Eycken; Olga P Pereshivko; Vsevolod A Peshkov
Journal:  Beilstein J Org Chem       Date:  2018-10-04       Impact factor: 2.883

3.  Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents.

Authors:  Sivan Perumal Murugan; Hong-Jie Zhong; Chih-Yu Wu; Hao-Wei Pan; Chinpiao Chen; Gene-Hsian Lee
Journal:  ACS Omega       Date:  2022-02-10
  3 in total

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