| Literature DB >> 27152453 |
Cong Wang1, Qingbao Li2, Fang Liu3, Xuan Chen1, Effat Un Nesa1, Shanghui Guan1, Bowen Liu1, Lihui Han1, Bingxu Tan1, Ding Wang4, Pengxiang Chen1, Xiaoyue Liu1, Han Zhang1, Ying Sun1, Yufeng Cheng1.
Abstract
We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC.Entities:
Keywords: Biomarker; diagnosis; esophageal cancer; miR-1297; qRT-PCR,
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Year: 2016 PMID： 27152453 DOI： 10.3109/1354750X.2016.1160291
Source DB: PubMed Journal: Biomarkers ISSN： 1354-750X Impact factor: 2.658