Karolina Chmaj-Wierzchowska1, Tomasz Olejniczak1, Jan Tuzel1, Joanna Niepsuj-Biniaś1, Izabela Kaczorowska1, Husam Samara2, Joanna Budna3, Anna Dera-Szymanowska4, Katarzyna Olejniczak5, Krzysztof Szymanowski1. 1. a Department of Maternal and Child Health , Poznan University of Medical Sciences , Poznan , Poland. 2. b Department of Immunology , Division of Clinical Immunology, Poznan University of Medical Sciences , Poznan , Poland. 3. c Department of Histology and Embryology , Poznan University of Medical Sciences , Poznan , Poland. 4. d Clinic of Perinatology and Gynecology, Poznan University of Medical Sciences , Poznan , Poland , and. 5. e Department of Pediatric Pulmonology , Allergy and Clinical Immunology, IIIrd Departments of Pediatrics, Poznan University of Medical Sciences , Poznan , Poland.
Abstract
OBJECTIVE: Preterm labour is defined as the onset of labour between weeks 23 and before 37 of gestation. The purpose of this study was to compare the cytokine profile in the blood serum of patients experiencing threatened premature labour, along with the time of delivery and the foetus body mass at birth. METHODS: The study included 89 women hospitalised at the Obstetrics and Gynaecology Clinical Hospital in the period 2011-2013. Group 1 comprised 31 patients diagnosed with threatened preterm labour, prior to tocolytic treatment. Group 2 comprised 32 patients with tocolytic treatment. Group 3 constituted the control group. RESULTS: Groups 1, 2 and 3 differed considerably in terms of the week of delivery of pregnancy (p = 0.006). Analogous results were obtained by analysing the body mass at birth, where a statistically significant difference in body mass at birth was found between Groups 1, 2 and 3 (p < 0.001). Our analysis focussed on the cytokine profile of the women included in the study, but no considerable changes in cytokine concentration were observed. CONCLUSIONS: No statistically significant differences were found in the cytokine profile among those patients in normally progressing pregnancy or in threatened preterm labour. No suitability of progesterone treatment in threatened preterm labour was observed.
OBJECTIVE: Preterm labour is defined as the onset of labour between weeks 23 and before 37 of gestation. The purpose of this study was to compare the cytokine profile in the blood serum of patients experiencing threatened premature labour, along with the time of delivery and the foetus body mass at birth. METHODS: The study included 89 women hospitalised at the Obstetrics and Gynaecology Clinical Hospital in the period 2011-2013. Group 1 comprised 31 patients diagnosed with threatened preterm labour, prior to tocolytic treatment. Group 2 comprised 32 patients with tocolytic treatment. Group 3 constituted the control group. RESULTS: Groups 1, 2 and 3 differed considerably in terms of the week of delivery of pregnancy (p = 0.006). Analogous results were obtained by analysing the body mass at birth, where a statistically significant difference in body mass at birth was found between Groups 1, 2 and 3 (p < 0.001). Our analysis focussed on the cytokine profile of the women included in the study, but no considerable changes in cytokine concentration were observed. CONCLUSIONS: No statistically significant differences were found in the cytokine profile among those patients in normally progressing pregnancy or in threatened preterm labour. No suitability of progesterone treatment in threatened preterm labour was observed.
Entities:
Keywords:
Delivery; infections; neonatology; physiology of reproduction; prenatal care