Literature DB >> 27151292

Replication protein A and more: single-stranded DNA-binding proteins in eukaryotic cells.

Ting Liu1, Jun Huang2.   

Abstract

Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombinational repair, and maintenance of genome stability. In human, the major SSB, replication protein A (RPA), is a stable heterotrimer composed of subunits of RPA1, RPA2, and RPA3, each of which is conserved not only in mammals but also in all other eukaryotic species. In addition to RPA, other SSBs have also been identified in the human genome, including sensor of single-stranded DNA complexes 1 and 2 (SOSS1/2). In this review, we summarize our current understanding of how these SSBs contribute to the maintenance of genome stability.
© The Author 2016. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  genome instability; replication protein A; sensor of single-stranded DNA complex; single-stranded DNA-binding proteins

Mesh：

Substances：

Year:  2016        PMID： 27151292     DOI： 10.1093/abbs/gmw041

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  9 in total

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Authors:  Miguel Garavís; Olga Calvo
Journal:  Curr Genet       Date:  2017-05-31       Impact factor: 3.886

2.  Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells.

Authors:  Xiaolong Wei; Jiekun Yang; Sara J Adair; Harun Ozturk; Cem Kuscu; Kyung Yong Lee; William J Kane; Patrick E O'Hara; Denis Liu; Yusuf Mert Demirlenk; Alaa Hamdi Habieb; Ebru Yilmaz; Anindya Dutta; Todd W Bauer; Mazhar Adli
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-23       Impact factor: 11.205

3.  RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma.

Authors:  Chen Qu; Yiying Zhao; Guokai Feng; Chen Chen; Yalan Tao; Shu Zhou; Songran Liu; Hui Chang; Musheng Zeng; Yunfei Xia
Journal:  J Cell Mol Med       Date:  2017-05-30       Impact factor: 5.310

Review 4.  Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems.

Authors:  Marcelo S da Silva; Raphael S Pavani; Jeziel D Damasceno; Catarina A Marques; Richard McCulloch; Luiz Ricardo Orsini Tosi; Maria Carolina Elias
Journal:  Trends Parasitol       Date:  2017-08-24

5.  The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.

Authors:  Anjali Gupta Hinch; Philipp W Becker; Tao Li; Daniela Moralli; Gang Zhang; Clare Bycroft; Catherine Green; Scott Keeney; Qinghua Shi; Benjamin Davies; Peter Donnelly
Journal:  Mol Cell       Date:  2020-06-30       Impact factor: 17.970

6.  Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts.

Authors:  Yun-Miao Guo; Jie-Rong Chen; Yan-Chun Feng; Melvin L K Chua; Yanni Zeng; Edwin Pun Hui; Allen K C Chan; Lin-Quan Tang; Lin Wang; Qian Cui; Hui-Qiong Han; Chun-Ling Luo; Guo-Wang Lin; Yan Liang; Yang Liu; Zhong-Lian He; Yu-Xiang Liu; Pan-Pan Wei; Chu-Jun Liu; Wan Peng; Bo-Wei Han; Xiao-Yu Zuo; Enya H W Ong; Eugenia L L Yeo; Kar Perng Low; Gek San Tan; Tony K H Lim; Jacqueline S G Hwang; Bo Li; Qi-Sheng Feng; Xiaojun Xia; Yun-Fei Xia; Josephine Ko; Wei Dai; Maria L Lung; Anthony T C Chan; Dennis Y M Lo; Mu-Sheng Zeng; Hai-Qiang Mai; Jianjun Liu; Yi-Xin Zeng; Jin-Xin Bei
Journal:  Adv Sci (Weinh)       Date:  2020-03-20       Impact factor: 16.806

Review 7.  DNA Damage Repair in Brain Tumor Immunotherapy.

Authors:  Shihong Zhao; Boya Xu; Wenbin Ma; Hao Chen; Chuanlu Jiang; Jinquan Cai; Xiangqi Meng
Journal:  Front Immunol       Date:  2022-01-13       Impact factor: 7.561

8.  Ailanthone inhibits non-small cell lung cancer cell growth through repressing DNA replication via downregulating RPA1.

Authors:  Zhongya Ni; Chao Yao; Xiaowen Zhu; Chenyuan Gong; Zihang Xu; Lixin Wang; Suyun Li; Chunpu Zou; Shiguo Zhu
Journal:  Br J Cancer       Date:  2017-10-12       Impact factor: 7.640

9.  Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells.

Authors:  Henriette Pedersen; Elisabeth Anne Adanma Obara; Kirstine Juul Elbæk; Kristoffer Vitting-Serup; Petra Hamerlik
Journal:  Int J Mol Sci       Date:  2020-02-26       Impact factor: 5.923
  9 in total

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