Literature DB >> 27150533

Cabozantinib Approved for Renal Cell Carcinoma.

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Abstract

The FDA has approved cabozantinib, a tyrosine kinase inhibitor, for patients with advanced renal cell carcinoma who have received prior antiangiogenic therapy. In a randomized phase III trial, participants who received cabozantinib did better across three efficacy endpoints-progression-free survival, overall survival, and objective response rate-than those given the mTOR inhibitor everolimus. ©2016 American Association for Cancer Research.

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Year:  2016        PMID: 27150533     DOI: 10.1158/2159-8290.CD-NB2016-057

Source DB:  PubMed          Journal:  Cancer Discov        ISSN: 2159-8274            Impact factor:   39.397


  2 in total

1.  Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial.

Authors:  Michael J Fisher; Chie-Schin Shih; Steven D Rhodes; Amy E Armstrong; Pamela L Wolters; Eva Dombi; Chi Zhang; Steven P Angus; Gary L Johnson; Roger J Packer; Jeffrey C Allen; Nicole J Ullrich; Stewart Goldman; David H Gutmann; Scott R Plotkin; Tena Rosser; Kent A Robertson; Brigitte C Widemann; Abbi E Smith; Waylan K Bessler; Yongzheng He; Su-Jung Park; Julie A Mund; Li Jiang; Khadijeh Bijangi-Vishehsaraei; Coretta Thomas Robinson; Gary R Cutter; Bruce R Korf; Jaishri O Blakeley; D Wade Clapp
Journal:  Nat Med       Date:  2021-01-13       Impact factor: 53.440

2.  Immunological effects of everolimus in patients with metastatic renal cell cancer.

Authors:  Charlotte M Huijts; Saskia J Santegoets; Tamarah D de Jong; Henk M Verheul; Tanja D de Gruijl; Hans J van der Vliet
Journal:  Int J Immunopathol Pharmacol       Date:  2017-10-09       Impact factor: 3.219

  2 in total

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