Literature DB >> 2715047

Quantitative immunohistochemistry of metallothionein in rat placenta.

W Hazelhoff Roelfzema1, C Tohyama, H Nishimura, N Nishimura, A F Morselt.   

Abstract

The presence of metallothionein (MT) was demonstrated in placentae from cadmium-exposed and control rats by an immunohistochemical technique, using peroxidase as label and the diaminobenzidine procedure for the staining reaction. The protein was found in different regions of the placenta, i.e. in trophoblastic labyrinth, in spongiotrophoblast and in visceral yolk sac. Cytophotometric analysis of the final reaction product revealed that the amount of MT was increased in the placental labyrinth of cadmium-exposed rats. Increases were found in both nuclei and cytoplasm of trophoblast cells in the labyrinth region. Possible roles of MT in the transport of zinc and in the carbohydrate metabolism are discussed.

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Year:  1989        PMID： 2715047     DOI： 10.1007/BF00508314

Source DB:  PubMed          Journal:  Histochemistry        ISSN： 0301-5564


  19 in total

1.  VASCULAR CHANGES AT SITES OF OESTROGEN BIOSYNTHESIS PRODUCED BY PARENTERAL INJECTION OF CADMIUM SALTS: THE DESTRUCTION OF PLACENTA BY CADMIUM SALTS.

Authors:  J PARIZEK
Journal:  J Reprod Fertil       Date:  1964-04

2.  The out-of-range error in microdensitometry.

Authors:  C J Van Noorden; R G Butcher
Journal:  Histochem J       Date:  1986-07

Review 3.  Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation.

Authors:  D M Ziegler
Journal:  Annu Rev Biochem       Date:  1985       Impact factor: 23.643

Review 4.  Tissue localization of some teratogens at early and late gestation related to fetal effects.

Authors:  L Dencker
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1976

5.  Placental toxicity of cadmium in the rat: an ultrastructural study.

Authors:  P A Di Sant'Agnese; K D Jensen; A Levin; R K Miller
Journal:  Placenta       Date:  1983 Apr-Jun       Impact factor: 3.481

6.  Effect of cadmium on prenatal development and on tissue cadmium, copper, and zinc concentrations in rats.

Authors:  B Barański
Journal:  Environ Res       Date:  1987-02       Impact factor: 6.498

7.  Glycogen content of placenta and of fetal and maternal liver in cadmium-exposed rats. I: A descriptive light microscopic study.

Authors:  W Hazelhoff Roelfzema; A M Roelofsen; J H Peereboom-Stegeman
Journal:  Placenta       Date:  1987 Jan-Feb       Impact factor: 3.481

8.  Cadmium: placental mechanisms of fetal toxicity.

Authors:  A A Levin; J R Plautz; P A di Sant'Agnese; R K Miller
Journal:  Placenta Suppl       Date:  1981

9.  Effect of oral cadmium administration to female rats before and/or during pregnancy on the metallothionein level in the fetal liver.

Authors:  B Sowa; E Steibert; K Gralewska; M Piekarski
Journal:  Toxicol Lett       Date:  1982-05       Impact factor: 4.372

10.  The influence of maternal cadmium exposure or fetal cadmium injection on hepatic metallothionein concentrations in the fetal rat.

Authors:  L B Sasser; B J Kelman; A A Levin; R K Miller
Journal:  Toxicol Appl Pharmacol       Date:  1985-09-15       Impact factor: 4.219
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  7 in total

1.  Quantitative immunogold study of increased expression of metallothionein-I/II in the brain perivascular areas of diabetic scrapie-infected mice.

Authors:  Andrzej W Vorbrodt; Danuta H Dobrogowska; Harry C Meeker; Richard I Carp
Journal:  J Mol Histol       Date:  2006-09-21       Impact factor: 2.611

2.  Isolation and identification of metallothionein isoforms (MT-1 and MT-2) in the rat testis.

Authors:  J S Suzuki; N Kodama; A Molotkov; E Aoki; C Tohyama
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

3.  Cadmium and zinc concentrations in fetal and maternal rat tissue after parenteral administration of cadmium during pregnancy.

Authors:  W Hazelhoff Roelfzema; A M Roelofsen; R F Herber; J H Peereboom-Steg
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

4.  The localization of mercury and metallothionein in the cerebellum of rats experimentally exposed to methylmercury.

Authors:  K Leyshon-Sørland; B Jasani; A J Morgan
Journal:  Histochem J       Date:  1994-02

5.  Immunohistochemical localization of metallothionein in the eye of rats.

Authors:  H Nishimura; N Nishimura; S Kobayashi; C Tohyama
Journal:  Histochemistry       Date:  1991

6.  Effects of cadmium exposure during pregnancy on cadmium and zinc concentrations in neonatal liver and consequences for the offspring.

Authors:  W Hazelhoff Roelfzema; A M Roelofsen; W Leene; H J Peereboom-Stegeman
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

7.  The ultrastructural localization of metallothionein in cadmium exposed rat liver.

Authors:  K Leyshon-Sørland; E Stang
Journal:  Histochem J       Date:  1993-12
  7 in total

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