Literature DB >> 27150374

Matrine: Bioactivities and Structural Modifications.

Jiulin Huang, Hui Xu1.   

Abstract

Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.

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Year:  2016        PMID： 27150374     DOI： 10.2174/1568026616666160506131012

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  15 in total

1.  Matrine suppresses cardiac fibrosis by inhibiting the TGF‑β/Smad pathway in experimental diabetic cardiomyopathy.

Authors:  Yong Zhang; Lei Cui; Gongchang Guan; Junkui Wang; Chuan Qiu; Tielin Yang; Yan Guo; Zhongwei Liu
Journal:  Mol Med Rep       Date:  2017-11-14       Impact factor: 2.952

2.  Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.

Authors:  Guojun Wu; Wenhong Zhou; Junfeng Zhao; Xiaohua Pan; Yongjie Sun; Hao Xu; Peng Shi; Chong Geng; Ling Gao; Xingsong Tian
Journal:  Oncotarget       Date:  2017-02-14

3.  Radix Sophorae Flavescentis induces apoptosis through by Caspase, MAPK Activation and ROS Signaling Pathways in 5637 Human Bladder Cancer Cells.

Authors:  Geoncheol Jo; Min Ji Kwon; Jeong Nam Kim; Byung Joo Kim
Journal:  Int J Med Sci       Date:  2020-06-15       Impact factor: 3.738

4.  Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling.

Authors:  Yuming Zou; Melika Sarem; Shengnan Xiang; Honggang Hu; Weidong Xu; V Prasad Shastri
Journal:  BMC Cancer       Date:  2019-10-15       Impact factor: 4.430

Review 5.  The Potential of Chinese Herbal Medicines in the Treatment of Cervical Cancer.

Authors:  Yi-Hsuan Hsiao; Chiao-Wen Lin; Po-Hui Wang; Min-Chien Hsin; Shun-Fa Yang
Journal:  Integr Cancer Ther       Date:  2019 Jan-Dec       Impact factor: 3.279

6.  Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways.

Authors:  Xi Zhang; Hui Xu; Xiaoyang Bi; Guoqing Hou; Andong Liu; Youyun Zhao; Guoping Wang; Xuan Cao
Journal:  Cell Death Dis       Date:  2021-10-12       Impact factor: 8.469

7.  Matrine protects colon mucosal epithelial cells against inflammation and apoptosis via the Janus kinase 2 /signal transducer and activator of transcription 3 pathway.

Authors:  Aimei Chen; Defang Fang; Yan Ren; Zhiyong Wang
Journal:  Bioengineered       Date:  2022-03       Impact factor: 3.269

8.  Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression.

Authors:  Hongtao Ren; Yali Wang; Ya Guo; Mincong Wang; Xiulong Ma; Wen Li; Yuyan Guo; Yiming Li
Journal:  Bioengineered       Date:  2022-04       Impact factor: 6.832

9.  Matrine Restrains Cell Growth and Metastasis by Up-Regulating LINC00472 in Bladder Carcinoma.

Authors:  Linlin Li; Fei Qi; Kaichen Wang
Journal:  Cancer Manag Res       Date:  2020-02-18       Impact factor: 3.989

10.  Matrine exerts anti‑breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF‑7 cells.

Authors:  Jikun Du; Jinwen Li; Daibo Song; Qin Li; Lin Li; Baohong Li; Li Li
Journal:  Mol Med Rep       Date:  2020-08-20       Impact factor: 2.952
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