| Literature DB >> 27150094 |
Ashley J Snider1,2,3, Agnieszka B Bialkowska2, Amr M Ghaleb2, Vincent W Yang2,4, Lina M Obeid1,2,3, Yusuf A Hannun2,3.
Abstract
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.Entities:
Keywords: AOM/DSS model; Azoxymethane; Colitis-associated cancer; Dextran sulfate sodium; Inflammatory bowel disease; Murine model
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Year: 2016 PMID： 27150094 PMCID： PMC5657253 DOI： 10.1007/978-1-4939-3661-8_14
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745