| Literature DB >> 27149392 |
Yi Liu1, Zhantong Wang2, Huimin Zhang2, Lixin Lang2, Ying Ma2, Qianjun He2, Nan Lu2, Peng Huang2, Yijing Liu2, Jibin Song2, Zhibo Liu2, Shi Gao3, Qingjie Ma3, Dale O Kiesewetter2, Xiaoyuan Chen2.
Abstract
A new type of photothermally responsive nanoprobe based on Edman degradation has been synthesized and characterized. Under irradiation by an 808 nm laser, the heat generated by the gold nanorod core breaks the thiocarbamide structure and releases the fluorescent dye Cy5.5 with increased near-infrared (NIR) fluorescence under mild acidic conditions. This RGD modified nanoprobe is capable of fluorescence imaging of ανβ3 over-expressing U87MG cells in vitro and in vivo. This Edman degradation-based nanoprobe provides a novel strategy to design activatable probes for biomedical imaging and drug/gene delivery.Entities:
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Year: 2016 PMID： 27149392 PMCID： PMC5223088 DOI： 10.1039/c6nr01400c
Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790