Literature DB >> 27149076

π(4)s + π(2)s Cycloaddition of Spiroepoxycyclohexa-2,4-dienone, Radical Cyclization, and Oxidation-Aldol-Oxidation Cascade: Synthesis of BCDE Ring of Atropurpuran.

Dnyandev B Jarhad1, Vishwakarma Singh1.   

Abstract

Synthesis of a tetracyclic ring system (BCDE) of atropurpuran is described. Oxidative dearomatization, cycloaddition of spiroepoxycyclohexa-2,4-dienone, radical cyclization, and a tandem oxidation-aldol-oxidation are the key features of our methodology.

Entities:  

Year:  2016        PMID： 27149076     DOI： 10.1021/acs.joc.6b00728

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Enantioselective Phenolic α-Oxidation Using H2O2 via an Unusual Double Dearomatization Mechanism.

Authors:  Michael F McLaughlin; Elisabetta Massolo; Shubin Liu; Jeffrey S Johnson
Journal:  J Am Chem Soc       Date:  2019-01-30       Impact factor: 15.419

Review 2.  Retrosynthetic strategies and their impact on synthesis of arcutane natural products.

Authors:  Shelby V McCowen; Nicolle A Doering; Richmond Sarpong
Journal:  Chem Sci       Date:  2020-04-21       Impact factor: 9.825

3.  Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells.

Authors:  Benjamin E Alexander; Sijia Sun; Matthew J Palframan; Gabriele Kociok-Köhn; Dya Fita Dibwe; Shiro Watanabe; Lorenzo Caggiano; Suresh Awale; Simon E Lewis
Journal:  ChemMedChem       Date:  2019-12-10       Impact factor: 3.466
  3 in total

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