M Tergestina1, G Rebekah2, V Job3, A Simon4, N Thomas1. 1. Department of Neonatology, Christian Medical College, Vellore, India. 2. Department of Biostatistics, Christian Medical College, Vellore, India. 3. Department of Biochemistry, Christian Medical College, Vellore, India. 4. Department of Child Health, Christian Medical College, Vellore, India.
Abstract
OBJECTIVE: To compare the efficacy of 400 vs 1000 IU oral vitamin D supplementation in preterm neonates of 27 to 34 weeks gestation. METHODS: This double-blind randomized controlled trial allocated preterm babies to receive either 400 or 1000 IU of vitamin D3 (n=60 in each group). Primary outcome was prevalence of vitamin D insufficiency (serum vitamin D levels<20 ng ml(-1)) at 40 weeks of corrected gestational age (CGA). RESULTS: At term CGA vitamin D insufficiency was significantly lower in the 1000 IU group than in the 400 IU group (2% vs 64.6%, P⩽0.001). Although elevated vitamin D levels were seen in 9.8% of babies on 1000 IU per day, this was not associated with clinical or biochemical evidence of toxicity. CONCLUSION: Supplementing preterm babies with 1000 IU of vitamin D3 daily decreases the prevalence of vitamin D insufficiency at term CGA. Excess levels of vitamin D may occur at this dose in some babies.
RCT Entities:
OBJECTIVE: To compare the efficacy of 400 vs 1000 IU oral vitamin D supplementation in preterm neonates of 27 to 34 weeks gestation. METHODS: This double-blind randomized controlled trial allocated preterm babies to receive either 400 or 1000 IU of vitamin D3 (n=60 in each group). Primary outcome was prevalence of vitamin Dinsufficiency (serum vitamin D levels<20 ng ml(-1)) at 40 weeks of corrected gestational age (CGA). RESULTS: At term CGA vitamin Dinsufficiency was significantly lower in the 1000 IU group than in the 400 IU group (2% vs 64.6%, P⩽0.001). Although elevated vitamin D levels were seen in 9.8% of babies on 1000 IU per day, this was not associated with clinical or biochemical evidence of toxicity. CONCLUSION: Supplementing preterm babies with 1000 IU of vitamin D3 daily decreases the prevalence of vitamin Dinsufficiency at term CGA. Excess levels of vitamin D may occur at this dose in some babies.
Authors: C Agostoni; G Buonocore; V P Carnielli; M De Curtis; D Darmaun; T Decsi; M Domellöf; N D Embleton; C Fusch; O Genzel-Boroviczeny; O Goulet; S C Kalhan; S Kolacek; B Koletzko; A Lapillonne; W Mihatsch; L Moreno; J Neu; B Poindexter; J Puntis; G Putet; J Rigo; A Riskin; B Salle; P Sauer; R Shamir; H Szajewska; P Thureen; D Turck; J B van Goudoever; E E Ziegler Journal: J Pediatr Gastroenterol Nutr Date: 2010-01 Impact factor: 2.839
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638