Literature DB >> 2714797

Definition of subchromosomal intervals around the myotonic dystrophy gene region at 19q.

D Schonk1, M Coerwinkel-Driessen, I van Dalen, F Oerlemans, B Smeets, J Schepens, T Hulsebos, D Cockburn, Y Boyd, M Davis.   

Abstract

The localization to 19q of the gene causing myotonic dystrophy (DM) has been defined more precisely by refinement of the physical location of several linked markers. A somatic cell hybrid mapping panel from cells with t(1;19), t(12;19), and t(X;19) translocation products was constructed to define five different intervals across 19q. In addition, we have derived a series of cell hybrids by irradiation of a der(19)-only hybrid to further subdivide the cen-q13.1 region. Using an array of 36 cloned genes, anonymous DNAs, and enzyme markers, we have tested the location of the panel breakpoints and refined the regional assignment of several of these markers. All markers tightly linked to DM are localized mainly within 19q13.2, thus suggesting that the DM gene is also close to this region.

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Year:  1989        PMID： 2714797     DOI： 10.1016/0888-7543(89)90346-7

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  28 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

Authors:  J D Brook; S J Knight; S H Roberts; H G Harley; K V Walsh; S A Rundle; K Freyne; M C Koch; N D Epstein; B Wieringa
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

3.  Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

Authors:  H G Harley; K V Walsh; S Rundle; J D Brook; M Sarfarazi; M C Koch; J L Floyd; P S Harper; D J Shaw
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

4.  Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers.

Authors:  S J Healy; J J Heffron; M Lehane; D G Bradley; K Johnson; T V McCarthy
Journal:  BMJ       Date:  1991-11-16

5.  An MspI RFLP detected by the human glandular kallikrein gene (hGK) on chromosome 19q.

Authors:  R Hermens; M Coerwinkel; J Trapman; P H Riegman; R J Vlietstra; H Smeets; B Wieringa
Journal:  Nucleic Acids Res       Date:  1990-01-11       Impact factor: 16.971

6.  Two polymorphisms at the DXS539 locus.

Authors:  J A van den Hurk; J C Dreesen; H van den Berg; C A van Bennekom; A M van den Ouweland; B A van Oost
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971

7.  New distal marker closely linked to the fragile X locus.

Authors:  T J Hulsebos; B A Oostra; S Broersen; A Smits; B A van Oost; A Westerveld
Journal:  Hum Genet       Date:  1991-07       Impact factor: 4.132

Review 8.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

9.  RN1, a new polymorphic marker near the fragile X locus. (HGM10 assignment DXS 369).

Authors:  P E Hupkes; C A van Bennekom; B A van Oost; B A Oostra
Journal:  Nucleic Acids Res       Date:  1990-02-11       Impact factor: 16.971

10.  Genetic mapping of X-linked albinism-deafness syndrome (ADFN) to Xq26.3-q27.I.

Authors:  Y Shiloh; G Litvak; Y Ziv; T Lehner; L Sandkuyl; M Hildesheimer; V Buchris; F P Cremers; P Szabo; B N White
Journal:  Am J Hum Genet       Date:  1990-07       Impact factor: 11.025
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