Literature DB >> 27147261

Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA.

A Manicardi1, E Gyssels, R Corradini, A Madder.   

Abstract

We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.

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Year:  2016        PMID： 27147261     DOI： 10.1039/c6cc02062c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Monitoring the Transcriptional Activity of Human Endogenous Retroviral HERV-W Family Using PNA Strand Invasion into Double-Stranded DNA.

Authors:  Grzegorz Machnik; Estera Skudrzyk; Łukasz Bułdak; Jarosław Ruczyński; Agnieszka Kozłowska; Piotr Mucha; Piotr Rekowski; Witold Szkróbka; Marcin Basiak; Aleksandra Bołdys; Helena Sławska; Bogusław Okopień
Journal:  Mol Biotechnol       Date:  2018-02       Impact factor: 2.695

2.  Clickable PNA Probes for Imaging Human Telomeres and Poly(A) RNAs.

Authors:  Pramod M Sabale; Uddhav B Ambi; Seergazhi G Srivatsan
Journal:  ACS Omega       Date:  2018-11-12

Review 3.  Antibacterial Peptide Nucleic Acids-Facts and Perspectives.

Authors:  Monika Wojciechowska; Marcin Równicki; Adam Mieczkowski; Joanna Miszkiewicz; Joanna Trylska
Journal:  Molecules       Date:  2020-01-28       Impact factor: 4.411

4.  Exploiting Double Exchange Diels-Alder Cycloadditions for Immobilization of Peptide Nucleic Acids on Gold Nanoparticles.

Authors:  Enrico Cadoni; Daniele Rosa-Gastaldo; Alex Manicardi; Fabrizio Mancin; Annemieke Madder
Journal:  Front Chem       Date:  2020-01-23       Impact factor: 5.221

5.  Synthesis and structure-activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown.

Authors:  Enrico Cadoni; Francesca Pennati; Penthip Muangkaew; Joke Elskens; Annemieke Madder; Alex Manicardi
Journal:  RSC Chem Biol       Date:  2022-07-21

6.  Visible-light triggered templated ligation on surface using furan-modified PNAs.

Authors:  Alex Manicardi; Enrico Cadoni; Annemieke Madder
Journal:  Chem Sci       Date:  2020-10-09       Impact factor: 9.825

7.  Synthesis and Improved Cross-Linking Properties of C5-Modified Furan Bearing PNAs.

Authors:  Joke Elskens; Alex Manicardi; Valentina Costi; Annemieke Madder; Roberto Corradini
Journal:  Molecules       Date:  2017-11-20       Impact factor: 4.411
  7 in total

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