Viola Walter1, Lina Jansen2, Alexis Ulrich3, Wilfried Roth4, Hendrik Bläker5, Jenny Chang-Claude6, Michael Hoffmeister2, Hermann Brenner7. 1. Division of Clinical Epidemiology and Aging Research, v.walter@dkfz.de. 2. Division of Clinical Epidemiology and Aging Research. 3. Departments of General, Visceral and Transplantation Surgery and. 4. Unit of Molecular Tumor Pathology, Pathology, Institute of Pathology, University Hospital, Heidelberg, Germany; and. 5. Institute of Pathology, Charité University Medicine, Berlin, Germany. 6. Division of Cancer Epidemiology, and. 7. Division of Clinical Epidemiology and Aging Research, German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, National Center for Tumor Diseases, Heidelberg, Germany;
Abstract
BACKGROUND: Studies on the association between alcohol consumption and colorectal cancer (CRC) prognosis have yielded inconsistent results. OBJECTIVE: The associations of lifetime and 1-y prediagnostic alcohol consumption with relevant prognostic outcomes were evaluated in a large population-based cohort of CRC patients. DESIGN: In 2003-2010, 3121 patients diagnosed with CRC were interviewed on sociodemographic and lifestyle factors, medication, and comorbidities. Cancer recurrence, vital status, and cause of death were documented for a median follow-up time of 4.8 y. With the use of Cox proportional hazard regression, associations between lifetime and recent alcohol consumption and overall, CRC-specific, recurrence-free, and disease-free survival were analyzed. RESULTS: In this patient cohort with a median age of 69 y at diagnosis, lifetime abstainers showed poorer overall [adjusted HR (aHR): 1.25; 95% CI: 1.03, 1.52] and CRC-specific (aHR: 1.37; 95% CI: 1.10, 1.70) survival than lifetime light drinkers (women: >0-12 g/d; men: >0-24 g/d). Lifetime heavy drinkers showed poorer overall (aHR: 1.37; 95% CI: 1.06, 1.78) and disease-free (aHR: 1.38; 95% CI: 1.09, 1.74) survival. Alcohol abstaining in the year before diagnosis was associated with poorer overall (aHR: 1.42; 95% CI: 1.20, 1.68), CRC-specific (aHR: 1.38; 95% CI: 1.13, 1.68), and disease-free (aHR: 1.23; 95% CI: 1.05, 1.44) survival. Lifetime abstainers with nonmetastatic disease showed poorer CRC-specific (aHR: 1.48; 95% CI: 1.10, 2.00) and recurrence-free (aHR: 1.32; 95% CI: 1.02, 1.70) survival. Wine abstaining but not beer or liquor abstaining was associated with poorer survival. Associations between alcohol consumption and prognosis varied according to presence of diabetes and age. CONCLUSIONS: Prediagnostic alcohol abstaining and heavy drinking were associated with poorer survival after a CRC diagnosis than light drinking. The protective effects of light consumption might be restricted to wine, and associations might differ according to age and presence of diabetes mellitus.
BACKGROUND: Studies on the association between alcohol consumption and colorectal cancer (CRC) prognosis have yielded inconsistent results. OBJECTIVE: The associations of lifetime and 1-y prediagnostic alcohol consumption with relevant prognostic outcomes were evaluated in a large population-based cohort of CRC patients. DESIGN: In 2003-2010, 3121 patients diagnosed with CRC were interviewed on sociodemographic and lifestyle factors, medication, and comorbidities. Cancer recurrence, vital status, and cause of death were documented for a median follow-up time of 4.8 y. With the use of Cox proportional hazard regression, associations between lifetime and recent alcohol consumption and overall, CRC-specific, recurrence-free, and disease-free survival were analyzed. RESULTS: In this patient cohort with a median age of 69 y at diagnosis, lifetime abstainers showed poorer overall [adjusted HR (aHR): 1.25; 95% CI: 1.03, 1.52] and CRC-specific (aHR: 1.37; 95% CI: 1.10, 1.70) survival than lifetime light drinkers (women: >0-12 g/d; men: >0-24 g/d). Lifetime heavy drinkers showed poorer overall (aHR: 1.37; 95% CI: 1.06, 1.78) and disease-free (aHR: 1.38; 95% CI: 1.09, 1.74) survival. Alcohol abstaining in the year before diagnosis was associated with poorer overall (aHR: 1.42; 95% CI: 1.20, 1.68), CRC-specific (aHR: 1.38; 95% CI: 1.13, 1.68), and disease-free (aHR: 1.23; 95% CI: 1.05, 1.44) survival. Lifetime abstainers with nonmetastatic disease showed poorer CRC-specific (aHR: 1.48; 95% CI: 1.10, 2.00) and recurrence-free (aHR: 1.32; 95% CI: 1.02, 1.70) survival. Wine abstaining but not beer or liquor abstaining was associated with poorer survival. Associations between alcohol consumption and prognosis varied according to presence of diabetes and age. CONCLUSIONS: Prediagnostic alcohol abstaining and heavy drinking were associated with poorer survival after a CRC diagnosis than light drinking. The protective effects of light consumption might be restricted to wine, and associations might differ according to age and presence of diabetes mellitus.
Authors: Doratha A Byrd; Tanya Agurs-Collins; David Berrigan; Richard Lee; Frances E Thompson Journal: J Racial Ethn Health Disparities Date: 2017-01-11
Authors: Yuhan Huang; Xinwei Hua; Julia D Labadie; Tabitha A Harrison; James Y Dai; Sara Lindstrom; Yi Lin; Sonja I Berndt; Daniel D Buchanan; Peter T Campbell; Graham Casey; Steven J Gallinger; Marc J Gunter; Michael Hoffmeister; Mark A Jenkins; Lori C Sakoda; Robert E Schoen; Brenda Diergaarde; Martha L Slattery; Emily White; Graham Giles; Hermann Brenner; Jenny Chang-Claude; Amit Joshi; Wenjie Ma; Rish K Pai; Andrew T Chan; Ulrike Peters; Polly A Newcomb Journal: Int J Cancer Date: 2022-01-13 Impact factor: 7.316
Authors: Lila E Mullany; Jennifer S Herrick; Roger K Wolff; John R Stevens; Martha L Slattery Journal: Cancer Causes Control Date: 2017-03-16 Impact factor: 2.506
Authors: Marco Rossi; Muhammad Jahanzaib Anwar; Ahmad Usman; Ali Keshavarzian; Faraz Bishehsari Journal: Cancers (Basel) Date: 2018-01-30 Impact factor: 6.639