| Literature DB >> 27146311 |
Brett Shook1, Guillermo Rivera Gonzalez1, Sarah Ebmeier1, Gabriella Grisotti2, Rachel Zwick1, Valerie Horsley1,3.
Abstract
Classically, white adipose tissue (WAT) was considered an inert component of connective tissue but is now appreciated as a major regulator of metabolic physiology and endocrine homeostasis. Recent work defining how WAT develops and expands in vivo emphasizes the importance of specific locations of WAT or depots in metabolic regulation. Interestingly, mature white adipocytes are integrated into several tissues. A new perspective regarding the in vivo regulation and function of WAT in these tissues has highlighted an essential role of adipocytes in tissue homeostasis and regeneration. Finally, there has been significant progress in understanding how mature adipocytes regulate the pathology of several diseases. In this review, we discuss these novel roles of WAT in the homeostasis and regeneration of epithelial, muscle, and immune tissues and how they contribute to the pathology of several disorders.Entities:
Keywords: adipocyte; adipose tissue; regeneration; skin
Mesh：
Year: 2016 PMID： 27146311 PMCID： PMC5157158 DOI： 10.1146/annurev-cellbio-111315-125426
Source DB: PubMed Journal: Annu Rev Cell Dev Biol ISSN： 1081-0706 Impact factor: 13.827