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Literature DB >> 27145954

[Immunosuppression after corneal transplantation : Clinical standards and novel approaches].

Abstract

Corticosteroid eye drops are the mainstay of immunosuppressive therapy after routine lamellar and perforating corneal transplantation. Commonly occurring side effects are cataract formation and increased intraocular pressure. Alternative immunosuppressive agents could allow the dosage of glucocorticoids to be reduced. The antibiotic azithromycin is a candidate drug that showed anti-inflammatory properties in cell cultures and animal models and has positive effects on transplant rejection.

Entities: Chemical Disease

Keywords: Anti-inflammatory agents; Azithromycin; Corneal transplantation; Glucocorticoids; Graft rejection

Mesh：

Substances：

Year: 2016 PMID： 27145954 DOI： 10.1007/s00347-016-0268-y

Source DB: PubMed Journal: Ophthalmologe ISSN： 0941-293X Impact factor: 1.059

12 in total

1. Outcomes of Descemet membrane endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty from a single centre study.

Authors: S Heinzelmann; D Böhringer; P Eberwein; T Reinhard; P Maier
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2016-01-07 Impact factor: 3.117

2. Randomized comparison of topical prednisolone acetate 1% versus fluorometholone 0.1% in the first year after descemet membrane endothelial keratoplasty.

Authors: Marianne O Price; Francis W Price; Friedrich E Kruse; Bjöern O Bachmann; Theofilos Tourtas
Journal: Cornea Date: 2014-09 Impact factor: 2.651

3. A comparison of azithromycin and tobramycin eye drops on epithelial wound healing and tolerance after penetrating keratoplasty.

Authors: Julie Blavin; Arnaud Sauer; Maher Saleh; David Gaucher; Claude Speeg-Schatz; Tristan Bourcier
Journal: J Ocul Pharmacol Ther Date: 2012-03-15 Impact factor: 2.671

4. Prevention and treatment of corneal graft rejection: current practice patterns of the Cornea Society (2011).

Authors: Bhairavi Kharod-Dholakia; J Bradley Randleman; Jennifer G Bromley; R Doyle Stulting
Journal: Cornea Date: 2015-06 Impact factor: 2.651

5. Effect of Topically Applied Azithromycin on Corneal Epithelial and Endothelial Apoptosis in a Rat Model of Corneal Alkali Burn.

Authors: Sedat Arikan; Turan Karaca; Yusuf Haydar Ertekin; Arzu Taskiran Comez; Ismail Ersan; Selim Demirtas; Sait Elmas; Hasan Ali Tufan; Hakan Turkon
Journal: Cornea Date: 2016-04 Impact factor: 2.651

6. Azithromycin for prevention of exacerbations of COPD.

Authors: Richard K Albert; John Connett; William C Bailey; Richard Casaburi; J Allen D Cooper; Gerard J Criner; Jeffrey L Curtis; Mark T Dransfield; Meilan K Han; Stephen C Lazarus; Barry Make; Nathaniel Marchetti; Fernando J Martinez; Nancy E Madinger; Charlene McEvoy; Dennis E Niewoehner; Janos Porsasz; Connie S Price; John Reilly; Paul D Scanlon; Frank C Sciurba; Steven M Scharf; George R Washko; Prescott G Woodruff; Nicholas R Anthonisen
Journal: N Engl J Med Date: 2011-08-25 Impact factor: 91.245

7. Systemic mycophenolate mofetil in comparison with systemic cyclosporin A in high-risk keratoplasty patients: 3 years' results of a randomized prospective clinical trial.

Authors: T Reinhard; A Reis; D Böhringer; M Malinowski; A Voiculescu; P Heering; E Godehardt; R Sunmacher
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2001-06 Impact factor: 3.117

[Immunosuppression after corneal transplantation : Clinical standards and novel approaches].

1. Outcomes of Descemet membrane endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty from a single centre study.

2. Randomized comparison of topical prednisolone acetate 1% versus fluorometholone 0.1% in the first year after descemet membrane endothelial keratoplasty.

3. A comparison of azithromycin and tobramycin eye drops on epithelial wound healing and tolerance after penetrating keratoplasty.

4. Prevention and treatment of corneal graft rejection: current practice patterns of the Cornea Society (2011).

5. Effect of Topically Applied Azithromycin on Corneal Epithelial and Endothelial Apoptosis in a Rat Model of Corneal Alkali Burn.

6. Azithromycin for prevention of exacerbations of COPD.

7. Systemic mycophenolate mofetil in comparison with systemic cyclosporin A in high-risk keratoplasty patients: 3 years' results of a randomized prospective clinical trial.

8. Effect of topical azithromycin on corneal innate immune responses.

9. Azithromycin treatment increases survival of high-risk corneal allotransplants.

10. Short-term azithromycin treatment promotes cornea allograft survival in the rat.

1. ALT (allogeneic limbal transplantation): a new surgical technique for limbal stem cell deficiency.

Review 2. An eye for azithromycin: review of the literature.