Aiste Kadziauskiene1,2, Kristina Kuoliene1,2, Rimvydas Asoklis1,2, Eugenijus Lesinskas1,3, Leopold Schmetterer4,5. 1. Faculty of Medicine, Vilnius University, Vilnius, Lithuania. 2. Centre of Eye Diseases, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania. 3. Centre of Ear, Nose and Throat, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania. 4. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. 5. Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Abstract
PURPOSE: To evaluate the changes of peripapillary and subfoveal choroidal thickness (CT) after trabeculectomy. METHODS: Prospective longitudinal study included 37 eyes with open-angle glaucoma. The subfoveal and peripapillary CT was measured using enhanced depth imaging spectral domain optical coherence tomography before trabeculectomy and 1 week, 3 and 6 months postoperatively. The associations between changes in the CT, intraocular pressure (IOP) and axial length were analysed. RESULTS: The medium subfoveal CT (IQR) increased from 182 (97) μm at baseline to 267 (107) μm 1 week, 213 (97) μm 3 months and 207 (91) μm 6 months postoperatively (p < 0.001). The peripapillary CT increased in all four quadrants at all follow-ups (p < 0.05). The subfoveal and peripapillary choroidal thickening correlated with the magnitude of IOP reduction (p < 0.05) and axial length shortening (p < 0.01) during whole follow-up period. There was a peripapillary CT increase of 2.9 μm per mmHg of IOP reduction (p < 0.001, CI 1.5-4.4) and 4.8 μm per mm of baseline axial length (p = 0.049, CI 0.03-9.6) 1 week postoperatively after adjustment for baseline IOP. Six months postoperatively, the decrease in axial length was the only factor associated with peripapillary choroidal thickening (p = 0.031; regression coefficient: 73.29 μm/mm, CI 7.1-139.5). CONCLUSION: Intraocular pressure (IOP) reduction after trabeculectomy caused the increase in subfoveal and peripapillary CT for at least 6 months postoperatively correlating with greater IOP reduction and axial length shortening. In the long term, the decrease in axial eye length, but not IOP, was the only factor to be associated with peripapillary choroidal thickening.
PURPOSE: To evaluate the changes of peripapillary and subfoveal choroidal thickness (CT) after trabeculectomy. METHODS: Prospective longitudinal study included 37 eyes with open-angle glaucoma. The subfoveal and peripapillary CT was measured using enhanced depth imaging spectral domain optical coherence tomography before trabeculectomy and 1 week, 3 and 6 months postoperatively. The associations between changes in the CT, intraocular pressure (IOP) and axial length were analysed. RESULTS: The medium subfoveal CT (IQR) increased from 182 (97) μm at baseline to 267 (107) μm 1 week, 213 (97) μm 3 months and 207 (91) μm 6 months postoperatively (p < 0.001). The peripapillary CT increased in all four quadrants at all follow-ups (p < 0.05). The subfoveal and peripapillary choroidal thickening correlated with the magnitude of IOP reduction (p < 0.05) and axial length shortening (p < 0.01) during whole follow-up period. There was a peripapillary CT increase of 2.9 μm per mmHg of IOP reduction (p < 0.001, CI 1.5-4.4) and 4.8 μm per mm of baseline axial length (p = 0.049, CI 0.03-9.6) 1 week postoperatively after adjustment for baseline IOP. Six months postoperatively, the decrease in axial length was the only factor associated with peripapillary choroidal thickening (p = 0.031; regression coefficient: 73.29 μm/mm, CI 7.1-139.5). CONCLUSION: Intraocular pressure (IOP) reduction after trabeculectomy caused the increase in subfoveal and peripapillary CT for at least 6 months postoperatively correlating with greater IOP reduction and axial length shortening. In the long term, the decrease in axial eye length, but not IOP, was the only factor to be associated with peripapillary choroidal thickening.
Authors: Ipek Oguz; Michael D Abramoff; Li Zhang; Kyungmoo Lee; Ellen Ziyi Zhang; Milan Sonka Journal: Invest Ophthalmol Vis Sci Date: 2016-07-01 Impact factor: 4.799
Authors: Seung Hyen Lee; Eun Ji Lee; Joon Mo Kim; Michaël J A Girard; Jean Martial Mari; Tae-Woo Kim Journal: Invest Ophthalmol Vis Sci Date: 2020-06-03 Impact factor: 4.799