Luke W Johnston1, Stewart B Harris1, Ravi Retnakaran1, Bernard Zinman1, Adria Giacca1, Zhen Liu1, Richard P Bazinet1, Anthony J Hanley1. 1. Department of Nutritional Sciences (L.W.J., Z.L., R.P.B., A.J.H.), University of Toronto, Toronto, ON M5S 3E2, Canada; Centre for Studies in Family Medicine (S.B.H.), University of Western Ontario, London, ON N6G 2M1, Canada; Division of Endocrinology (R.R., B.Z.), University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld Tanenbaum Research Institute (R.R., B.Z.), Mt Sinai Hospital, Toronto, ON M5T 3L9, Canada; Department of Physiology (A.G.), University of Toronto, Toronto, ON M5S 1A8, Canada; and Dalla Lana School of Public Health (A.J.H.), University of Toronto, Toronto, ON M5T 3M7, Canada.
Abstract
CONTEXT: Specific serum fatty acid (FA) profiles predict the development of incident type 2 diabetes; however, limited longitudinal data exist exploring their role in the progression of insulin sensitivity (IS) and β-cell function. OBJECTIVE: To examine the longitudinal associations of the FA composition of serum phospholipid (PL) and cholesteryl ester (CE) fractions with IS and β-cell function over 6 years. DESIGN: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort is a longitudinal observational study, with clinic visits occurring every 3 years. Three visits have been completed, totaling 6 years of follow-up. SETTING: Individuals (n = 477) at risk for diabetes recruited from the general population in London and Toronto, Canada. MAIN OUTCOME MEASURES: Values from an oral glucose tolerance test were used to compute 1/HOMA-IR and the Matsuda index for IS, the insulinogenic index over HOMA-IR, and the insulin secretion-sensitivity index-2 for β-cell function. Thin-layer chromatograph and gas chromatograph quantified FA. Generalized estimating equations were used for the analysis. RESULTS: IS and β-cell function declined by 8.3-19.4% over 6 years. In fully adjusted generalized estimating equation models, PL cis-vaccenate (18:1n-7) was positively associated with all outcomes, whereas γ-linolenate (GLA; 18:3n-6) and stearate (18:0) were negatively associated with IS. Tests for time interactions revealed that PL eicosadienoate (20:2n-6) and palmitate (16:0) and CE dihomo-γ-linolenate (20:3n-6), GLA, and palmitate had stronger associations with the outcomes after longer follow-up. CONCLUSIONS: In a Canadian population at risk for diabetes, we found that higher PL stearate and GLA and lower cis-vaccenic acid predicted consistently lower IS and β-cell function over 6 years.
CONTEXT: Specific serum fatty acid (FA) profiles predict the development of incident type 2 diabetes; however, limited longitudinal data exist exploring their role in the progression of insulin sensitivity (IS) and β-cell function. OBJECTIVE: To examine the longitudinal associations of the FA composition of serum phospholipid (PL) and cholesteryl ester (CE) fractions with IS and β-cell function over 6 years. DESIGN: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort is a longitudinal observational study, with clinic visits occurring every 3 years. Three visits have been completed, totaling 6 years of follow-up. SETTING: Individuals (n = 477) at risk for diabetes recruited from the general population in London and Toronto, Canada. MAIN OUTCOME MEASURES: Values from an oral glucose tolerance test were used to compute 1/HOMA-IR and the Matsuda index for IS, the insulinogenic index over HOMA-IR, and the insulin secretion-sensitivity index-2 for β-cell function. Thin-layer chromatograph and gas chromatograph quantified FA. Generalized estimating equations were used for the analysis. RESULTS: IS and β-cell function declined by 8.3-19.4% over 6 years. In fully adjusted generalized estimating equation models, PL cis-vaccenate (18:1n-7) was positively associated with all outcomes, whereas γ-linolenate (GLA; 18:3n-6) and stearate (18:0) were negatively associated with IS. Tests for time interactions revealed that PLeicosadienoate (20:2n-6) and palmitate (16:0) and CE dihomo-γ-linolenate (20:3n-6), GLA, and palmitate had stronger associations with the outcomes after longer follow-up. CONCLUSIONS: In a Canadian population at risk for diabetes, we found that higher PLstearate and GLA and lower cis-vaccenic acid predicted consistently lower IS and β-cell function over 6 years.
Authors: Luke W Johnston; Stewart B Harris; Ravi Retnakaran; Adria Giacca; Zhen Liu; Richard P Bazinet; Anthony J Hanley Journal: Diabetologia Date: 2017-12-24 Impact factor: 10.122
Authors: Luke W Johnston; Zhen Liu; Ravi Retnakaran; Bernard Zinman; Adria Giacca; Stewart B Harris; Richard P Bazinet; Anthony J Hanley Journal: J Lipid Res Date: 2018-07-09 Impact factor: 5.922
Authors: Elena Cristina Castillo; Leticia Elizondo-Montemayor; Carmen Hernández-Brenes; Dariana G Rodríguez-Sánchez; Christian Silva-Platas; Luis Martín Marín-Obispo; Nora A Rodríguez-Gutierrez; Víctor Treviño; Gerardo García-Rivas Journal: Oxid Med Cell Longev Date: 2020-08-11 Impact factor: 6.543