Literature DB >> 27144909

FADS2 genotype influences whole-body resting fat oxidation in young adult men.

Kaitlin Roke1,1, Sebastian Jannas-Vela1,1, Lawrence L Spriet1,1, David M Mutch1,1.   

Abstract

Considerable evidence supports an association between fatty acid desaturase 2 (FADS2) polymorphisms and the efficiency of converting alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA) via the desaturation-elongation pathway. However, ALA conversion into EPA represents only 1 of the metabolic fates for this essential fatty acid, as ALA is also highly oxidized. This study demonstrates for the first time that genetic variation in FADS2 (rs174576) is not only associated with the activity of the desaturation-elongation pathway, but also whole-body fat oxidation.

Entities:  

Keywords:  SNP; acide eicosapentaénoïque; acide gras désaturase; acide linolénique; eicosapentaenoic acid; fatty acid desaturase; linolenic acid; métabolisme de repos; oxidation; oxydation; resting metabolic rate

Mesh：

Substances：

Year:  2016        PMID： 27144909     DOI： 10.1139/apnm-2016-0043

Source DB:  PubMed          Journal:  Appl Physiol Nutr Metab        ISSN： 1715-5312            Impact factor:   2.665


  5 in total

1.  The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults.

Authors:  Valérie Lamantia; Simon Bissonnette; Viviane Provost; Marie Devaux; Yannick Cyr; Caroline Daneault; Christine Des Rosiers; May Faraj
Journal:  J Nutr       Date:  2019-01-01       Impact factor: 4.798

2.  Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention.

Authors:  Kaitlin Roke; Kathryn Walton; Shannon L Klingel; Amber Harnett; Sanjeena Subedi; Jess Haines; David M Mutch
Journal:  Nutrients       Date:  2017-03-06       Impact factor: 5.717

3.  Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition.

Authors:  Baojun Li; Liying Qiao; Lixia An; Weiwei Wang; Jianhua Liu; Youshe Ren; Yangyang Pan; Jiongjie Jing; Wenzhong Liu
Journal:  BMC Genomics       Date:  2018-05-08       Impact factor: 3.969

4.  Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population.

Authors:  Lijuan Zhao; Hong Chang; Dong-Sheng Zhou; Jun Cai; Weixing Fan; Wei Tang; Wenxin Tang; Xingxing Li; Weiqing Liu; Fang Liu; Yuanfang He; Yan Bai; Yan Sun; Jiapei Dai; Lingyi Li; Xiao Xiao; Chen Zhang; Ming Li
Journal:  Transl Psychiatry       Date:  2018-12-07       Impact factor: 6.222

5.  A novel polymorphism in the fatty acid desaturase 2 gene (Fads2): A possible role in the basal metabolic rate.

Authors:  Magdalena Czajkowska; Paweł Brzęk; Paweł Dobrzyń
Journal:  PLoS One       Date:  2019-02-28       Impact factor: 3.240
  5 in total

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