Christopher G Watson1, Mathieu Dehaes1, Borjan A Gagoski1, P Ellen Grant1, Michael J Rivkin2. 1. From the Departments of Neurology (C.G.W., M.J.R.), Psychiatry (M.J.R.), Radiology (P.E.G., M.J.R.), and Newborn Medicine (M.D., B.A.G., P.E.G.), Boston Children's Hospital, MA; Graduate Program for Neuroscience, Boston University, MA (C.G.W.); Department of Radiology, University of Montreal, Montreal, Quebec, Canada (M.D.); and Department of Radiology, Centre Hospitalier Universitaire Saint-Justine, Montreal, Quebec, Canada (M.D.). 2. From the Departments of Neurology (C.G.W., M.J.R.), Psychiatry (M.J.R.), Radiology (P.E.G., M.J.R.), and Newborn Medicine (M.D., B.A.G., P.E.G.), Boston Children's Hospital, MA; Graduate Program for Neuroscience, Boston University, MA (C.G.W.); Department of Radiology, University of Montreal, Montreal, Quebec, Canada (M.D.); and Department of Radiology, Centre Hospitalier Universitaire Saint-Justine, Montreal, Quebec, Canada (M.D.). michael.rivkin@childrens.harvard.edu.
Abstract
BACKGROUND AND PURPOSE: Perfusion-weighted imaging in adults with acute stroke often reveals hypoperfusion in the ischemic core and in a surrounding area of nondiffusion-restricted penumbral tissue. Perinatal stroke is common, but the perfusion pattern is rarely documented. We aimed to describe the perfusion pattern in newborns with perinatal stroke. METHODS: Neonates with clinical features of acute stroke underwent magnetic resonance imaging. Perfusion data were obtained using pseudocontinuous arterial spin labeling. Strokes were classified as arterial, venous, or both. Core infarction was determined by the presence of restricted diffusion on diffusion-weighted imaging. Perfusion-weighted imaging and susceptibility-weighted imaging signal in the ischemic area were visually compared with the homologous region in the contralesional hemisphere. Electroencephalogram data were evaluated for seizure activity. RESULTS: In 25 neonates with acute stroke, 8 of 11 (73%) with arterial ischemic stroke demonstrated hyperperfusion, 1 of 9 (11%) with venous stroke, and 4 of 5 (80%) with both. Hypoperfusion was observed in 3 of 9 (33%) with venous and none with arterial ischemic stroke. Perfusion was normal in 4 of 9 (45%) with venous and 1 of 5 (20%) with both. Twenty-one of 24 patients (88%) with electroencephalogram data had either electrographic seizures or focal sharp waves in the ipsilesional hemisphere (11/11 arterial ischemic stroke, 6/9 venous, and 4/5 both). CONCLUSIONS: Perfusion-weighted imaging can be obtained in neonates with acute stroke and often reveals hyperperfusion in the infarct core. Penumbra in arterial ischemic stroke is seldom found. Hyperperfusion may be caused by poststroke reperfusion or to neuronal hyperexcitability of stroke-associated seizure. Its identification may be useful for consideration of therapy for acute neonatal stroke.
BACKGROUND AND PURPOSE: Perfusion-weighted imaging in adults with acute stroke often reveals hypoperfusion in the ischemic core and in a surrounding area of nondiffusion-restricted penumbral tissue. Perinatal stroke is common, but the perfusion pattern is rarely documented. We aimed to describe the perfusion pattern in newborns with perinatal stroke. METHODS: Neonates with clinical features of acute stroke underwent magnetic resonance imaging. Perfusion data were obtained using pseudocontinuous arterial spin labeling. Strokes were classified as arterial, venous, or both. Core infarction was determined by the presence of restricted diffusion on diffusion-weighted imaging. Perfusion-weighted imaging and susceptibility-weighted imaging signal in the ischemic area were visually compared with the homologous region in the contralesional hemisphere. Electroencephalogram data were evaluated for seizure activity. RESULTS: In 25 neonates with acute stroke, 8 of 11 (73%) with arterial ischemic stroke demonstrated hyperperfusion, 1 of 9 (11%) with venous stroke, and 4 of 5 (80%) with both. Hypoperfusion was observed in 3 of 9 (33%) with venous and none with arterial ischemic stroke. Perfusion was normal in 4 of 9 (45%) with venous and 1 of 5 (20%) with both. Twenty-one of 24 patients (88%) with electroencephalogram data had either electrographic seizures or focal sharp waves in the ipsilesional hemisphere (11/11 arterial ischemic stroke, 6/9 venous, and 4/5 both). CONCLUSIONS: Perfusion-weighted imaging can be obtained in neonates with acute stroke and often reveals hyperperfusion in the infarct core. Penumbra in arterial ischemic stroke is seldom found. Hyperperfusion may be caused by poststroke reperfusion or to neuronal hyperexcitability of stroke-associated seizure. Its identification may be useful for consideration of therapy for acute neonatal stroke.
Authors: Helen L Carlson; Brandon T Craig; Alicia J Hilderley; Jacquie Hodge; Deepthi Rajashekar; Pauline Mouches; Nils D Forkert; Adam Kirton Journal: Neuroimage Clin Date: 2020-11-19 Impact factor: 4.881