Zariah A Aziz1, Yvonne Yl Lee2, Norsima Nazifah Sidek3, Bahari Awang Ngah4, Irene Looi5, Md Rafia Hanip6, Hamidon B Basri7. 1. a Department of Neurology and Clinical Research Centre , Hospital Sultanah Nur Zahirah , Kuala Terengganu , Malaysia. 2. b Health and Value, Pfizer Malaysia , Level 10 & 11, Wisma Averis , Kuala Lumpur , Malaysia. 3. d Board of Management , Hospital Sultan Haji Ahmad Shah , Temerloh , Malaysia. 4. c Department of Pharmacy , Hospital Sultanah Nur Zahirah , Kuala Terengganu , Malaysia. 5. e Department of Medicine and Clinical Research Centre , Hospital Seberang Jaya , Prai , Malaysia. 6. f Department of Neurology , Hospital Kuala Lumpur , Kuala Lumpur , Malaysia. 7. g Faculty of Medicine & Health Sciences, Department of Medicine , Universiti Putra Malaysia , Kuala Lumpur , Malaysia.
Abstract
OBJECTIVE: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke. METHODS: Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed. RESULTS: A total of 4762 first-ever ischemic stroke patients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender-age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis. DISCUSSION: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male.
OBJECTIVE: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke. METHODS: Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed. RESULTS: A total of 4762 first-ever ischemic strokepatients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender-age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis. DISCUSSION: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male.
Authors: Mariam Ali; Hendrikus J A van Os; Nelleke van der Weerd; Jan W Schoones; Martijn W Heymans; Nyika D Kruyt; Marieke C Visser; Marieke J H Wermer Journal: Stroke Date: 2021-12-14 Impact factor: 7.914
Authors: Heidi S Eddelien; Jawad H Butt; Thomas Christensen; Anne K Danielsen; Christina Kruuse Journal: Front Neurol Date: 2022-03-21 Impact factor: 4.003