| Literature DB >> 27142144 |
D Rathish1, S B Agampodi2, M A C S Jayasumana3, S H Siribaddana4.
Abstract
Organophosphate (OP) poisoning induced disruption of glucose homeostasis is well established. OP poisoning leads to accumulation of acetylcholine (ACh) due to the inhibition of acetylcholinesterases (AChE). On the other hand the incidence of type 2 diabetes mellitus (T2DM) is shown to rise along with the use of pesticides in Southeast Asia. Attenuation of the 'incretin effect' is seen in T2DM. This effect is regulated by a complex loop of mechanism involving ACh driven muscarinic receptors. We hypothesize that OP poisoning leads to disruption of glucose homeostasis by attenuation of the incretin effect. Inhibition of the Glucagon Like Peptide-1 (GLP-1) secretion is our main focus of interest. Positive finding of the hypothesis will open possibility of using incretin based treatment modalities to treat or prevent acute OP induced disruption of glucose homeostasis.Entities:
Keywords: Acetylcholine; Atropine; Glucagon Like Peptide-1; Glucose homeostasis; Incretins; Organophosphate; Type 2 diabetes mellitus
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Year: 2016 PMID： 27142144 DOI： 10.1016/j.mehy.2016.04.002
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538