Literature DB >> 2714209

Developmental toxicity testing with FETAX: evaluation of five compounds.

D A Dawson1, D J Fort, D L Newell, J A Bantle.   

Abstract

The teratogenic potential of five compounds was evaluated with FETAX (Frog Embryo Teratogenesis Assay: Xenopus). Early embryos of Xenopus laevis were exposed for 96 h to 6-aminonicotinamide (6-AN), isoniazid (INH), urethane, nitrilotriacetate (NTA) or sodium cyclamate, in two separate static-renewal tests of each compound. Based on Teratogenic Index values, growth endpoints and the types and severity of the induced malformations, 6-AN, INH and urethane scored as having strong teratogenic potential. NTA and sodium cyclamate had little or no teratogenic potential. The results support continued evaluation of FETAX as a screening assay for chemical teratogens.

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Year:  1989        PMID： 2714209     DOI： 10.3109/01480548908999144

Source DB:  PubMed          Journal:  Drug Chem Toxicol        ISSN： 0148-0545            Impact factor:   3.356


  6 in total

1.  Synergism and antagonism induced by three carrier solvents with t-retinoic acid and 6-aminonicotinamide using FETAX.

Authors:  J R Rayburn; D J Fort; R McNew; J A Bantle
Journal:  Bull Environ Contam Toxicol       Date:  1991-04       Impact factor: 2.151

2.  Rapid measurement of toxicity using electrochromic dyes and frog embryos.

Authors:  B K Stringer; J T Blankemeyer
Journal:  Bull Environ Contam Toxicol       Date:  1993-10       Impact factor: 2.151

3.  Teratogenicity of Ni2+ in Xenopus laevis, assayed by the FETAX procedure.

Authors:  S M Hopfer; M C Plowman; K R Sweeney; J A Bantle; F W Sunderman
Journal:  Biol Trace Elem Res       Date:  1991-06       Impact factor: 3.738

4.  Ecotoxicological effects of a nonionic detergent (Triton DF-16) assayed by modFETAX.

Authors:  C Presutti; C Vismara; M Camatini; G Bernardini
Journal:  Bull Environ Contam Toxicol       Date:  1994-09       Impact factor: 2.151

Review 5.  The need for water quality criteria for frogs.

Authors:  R Boyer; C E Grue
Journal:  Environ Health Perspect       Date:  1995-04       Impact factor: 9.031

Review 6.  Xenbase: Facilitating the Use of Xenopus to Model Human Disease.

Authors:  Mardi J Nenni; Malcolm E Fisher; Christina James-Zorn; Troy J Pells; Virgilio Ponferrada; Stanley Chu; Joshua D Fortriede; Kevin A Burns; Ying Wang; Vaneet S Lotay; Dong Zhou Wang; Erik Segerdell; Praneet Chaturvedi; Kamran Karimi; Peter D Vize; Aaron M Zorn
Journal:  Front Physiol       Date:  2019-02-26       Impact factor: 4.566
  6 in total

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