Literature DB >> 27141877

Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives.

Xiaolin Lu1, Gaochao Dong2, Ying Zheng1, Chao Zhang3, Yang Qiu1, Tao Lua3, Xiang Zhou1.   

Abstract

OBJECTIVE/
METHOD: A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro. RESULT: Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell line (A375) in vitro, which was valuable to study further. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  4H-Chromen-4-one; BRAF (V600E) kinase; anticancer activity; design; in vitro; synthesis

Mesh：

Substances：

Year:  2017        PMID： 27141877     DOI： 10.2174/1871520615666160504094945

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  1 in total

1.  A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced MMP9 Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells.

Authors:  Munki Jeong; Euitaek Jung; Young Han Lee; Jeong Kon Seo; Seunghyun Ahn; Dongsoo Koh; Yoongho Lim; Soon Young Shin
Journal:  Int J Mol Sci       Date:  2020-07-18       Impact factor: 5.923
  1 in total

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