Literature DB >> 27141407

Secreted microRNAs from tumor cells can suppress immune function.

Xi Chen1, Hongwei Liang1, Ke Zen1, Chen-Yu Zhang1.   

Abstract

Our recent study reported an interesting finding that tumor cells can actively manipulate host immune function to facilitate tumor immune escape through the secretion of microRNAs (miRNAs). As an extension of this finding, we showed that blockage of the function of tumor-secreted miRNAs represents an effective therapeutic approach for cancer treatment.

Entities:  

Keywords:  PTEN; microvesicle; regulatory T cell; secreted microRNA; tumor immune escape

Year:  2016        PMID： 27141407      PMCID： PMC4839375          DOI： 10.4161/2162402X.2014.982407

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  MicroRNAs: genomics, biogenesis, mechanism, and function.

Authors:  David P Bartel
Journal:  Cell       Date:  2004-01-23       Impact factor: 41.582

2.  Secretory mechanisms and intercellular transfer of microRNAs in living cells.

Authors:  Nobuyoshi Kosaka; Haruhisa Iguchi; Yusuke Yoshioka; Fumitaka Takeshita; Yasushi Matsuki; Takahiro Ochiya
Journal:  J Biol Chem       Date:  2010-03-30       Impact factor: 5.157

3.  PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.

Authors:  Patrick T Walsh; Jodi L Buckler; Jidong Zhang; Andrew E Gelman; Nicole M Dalton; Devon K Taylor; Steven J Bensinger; Wayne W Hancock; Laurence A Turka
Journal:  J Clin Invest       Date:  2006-08-17       Impact factor: 14.808

4.  Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7.

Authors:  Wei A He; Federica Calore; Priya Londhe; Alessandro Canella; Denis C Guttridge; Carlo M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-10       Impact factor: 11.205

Review 5.  Basic principles of tumor-associated regulatory T cell biology.

Authors:  Peter A Savage; Sven Malchow; Daniel S Leventhal
Journal:  Trends Immunol       Date:  2012-09-19       Impact factor: 16.687

6.  Secreted monocytic miR-150 enhances targeted endothelial cell migration.

Authors:  Yujing Zhang; Danqing Liu; Xi Chen; Jing Li; Limin Li; Zhen Bian; Fei Sun; Jiuwei Lu; Yuan Yin; Xing Cai; Qi Sun; Kehui Wang; Yi Ba; Qiang Wang; Dongjin Wang; Junwei Yang; Pingsheng Liu; Tao Xu; Qiao Yan; Junfeng Zhang; Ke Zen; Chen-Yu Zhang
Journal:  Mol Cell       Date:  2010-07-09       Impact factor: 17.970

7.  Circulating microRNAs as stable blood-based markers for cancer detection.

Authors:  Patrick S Mitchell; Rachael K Parkin; Evan M Kroh; Brian R Fritz; Stacia K Wyman; Era L Pogosova-Agadjanyan; Amelia Peterson; Jennifer Noteboom; Kathy C O'Briant; April Allen; Daniel W Lin; Nicole Urban; Charles W Drescher; Beatrice S Knudsen; Derek L Stirewalt; Robert Gentleman; Robert L Vessella; Peter S Nelson; Daniel B Martin; Muneesh Tewari
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-28       Impact factor: 11.205

8.  Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases.

Authors:  Xi Chen; Yi Ba; Lijia Ma; Xing Cai; Yuan Yin; Kehui Wang; Jigang Guo; Yujing Zhang; Jiangning Chen; Xing Guo; Qibin Li; Xiaoying Li; Wenjing Wang; Yan Zhang; Jin Wang; Xueyuan Jiang; Yang Xiang; Chen Xu; Pingping Zheng; Juanbin Zhang; Ruiqiang Li; Hongjie Zhang; Xiaobin Shang; Ting Gong; Guang Ning; Jun Wang; Ke Zen; Junfeng Zhang; Chen-Yu Zhang
Journal:  Cell Res       Date:  2008-10       Impact factor: 25.617

9.  Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

Authors:  Weiying Zhou; Miranda Y Fong; Yongfen Min; George Somlo; Liang Liu; Melanie R Palomares; Yang Yu; Amy Chow; Sean Timothy Francis O'Connor; Andrew R Chin; Yun Yen; Yafan Wang; Eric G Marcusson; Peiguo Chu; Jun Wu; Xiwei Wu; Arthur Xuejun Li; Zhuo Li; Hanlin Gao; Xiubao Ren; Mark P Boldin; Pengnian Charles Lin; Shizhen Emily Wang
Journal:  Cancer Cell       Date:  2014-04-14       Impact factor: 31.743

10.  Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth.

Authors:  Yuan Yin; Xing Cai; Xi Chen; Hongwei Liang; Yujing Zhang; Jing Li; Zuoyun Wang; Xiulan Chen; Wen Zhang; Seiji Yokoyama; Cheng Wang; Liang Li; Limin Li; Dongxia Hou; Lei Dong; Tao Xu; Takachika Hiroi; Fuquan Yang; Hongbin Ji; Junfeng Zhang; Ke Zen; Chen-Yu Zhang
Journal:  Cell Res       Date:  2014-09-16       Impact factor: 25.617
  10 in total
  3 in total

Review 1.  The biology of extracellular microvesicles.

Authors:  Alanna E Sedgwick; Crislyn D'Souza-Schorey
Journal:  Traffic       Date:  2018-03-25       Impact factor: 6.215

Review 2.  Blood-based biomarkers for the diagnosis and monitoring of gliomas.

Authors:  Marcus A Zachariah; Joao Paulo Oliveira-Costa; Bob S Carter; Shannon L Stott; Brian V Nahed
Journal:  Neuro Oncol       Date:  2018-08-02       Impact factor: 12.300

Review 3.  Dietary non-coding RNAs from plants: Fairy tale or treasure?

Authors:  Gopinath M Sundaram
Journal:  Noncoding RNA Res       Date:  2019-02-21
  3 in total

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