Literature DB >> 27141402

Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity.

Wan-Chen Cheng1, Ping-Chih Ho1.   

Abstract

Glycolytic activity in T cells governs T cell responses by controlling various cellular processes, including proliferation, survival, and effector functions. We recently showed that the tumor microenvironment diminishes T cell antitumor responses by depriving glucose to infiltrating T cells. Moreover, metabolic rewiring tumor-reactive T cells sustain T cell metabolic fitness and antitumor responses.

Entities:  

Keywords:  Immunotherapy; PEP; immune checkpoint; metabolic reprogramming; tumor infiltrating T cell

Year:  2015        PMID： 27141402      PMCID： PMC4839318          DOI： 10.1080/2162402X.2015.1119355

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  9 in total

Review 1.  Metabolic regulation of T lymphocytes.

Authors:  Nancie J MacIver; Ryan D Michalek; Jeffrey C Rathmell
Journal:  Annu Rev Immunol       Date:  2013-01-03       Impact factor: 28.527

2.  Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch.

Authors:  Patrick M Gubser; Glenn R Bantug; Leyla Razik; Marco Fischer; Sarah Dimeloe; Gideon Hoenger; Bojana Durovic; Annaïse Jauch; Christoph Hess
Journal:  Nat Immunol       Date:  2013-08-18       Impact factor: 25.606

3.  Posttranscriptional control of T cell effector function by aerobic glycolysis.

Authors:  Chih-Hao Chang; Jonathan D Curtis; Leonard B Maggi; Brandon Faubert; Alejandro V Villarino; David O'Sullivan; Stanley Ching-Cheng Huang; Gerritje J W van der Windt; Julianna Blagih; Jing Qiu; Jason D Weber; Edward J Pearce; Russell G Jones; Erika L Pearce
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

Review 4.  Regulation of cancer cell metabolism.

Authors:  Rob A Cairns; Isaac S Harris; Tak W Mak
Journal:  Nat Rev Cancer       Date:  2011-02       Impact factor: 60.716

5.  The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.

Authors:  Matthew M Staron; Simon M Gray; Heather D Marshall; Ian A Parish; Jonathan H Chen; Curtis J Perry; Guoliang Cui; Ming O Li; Susan M Kaech
Journal:  Immunity       Date:  2014-11-13       Impact factor: 31.745

6.  Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

Authors:  Chih-Hao Chang; Jing Qiu; David O'Sullivan; Michael D Buck; Takuro Noguchi; Jonathan D Curtis; Qiongyu Chen; Mariel Gindin; Matthew M Gubin; Gerritje J W van der Windt; Elena Tonc; Robert D Schreiber; Edward J Pearce; Erika L Pearce
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582

Review 7.  Metabolic pathways in immune cell activation and quiescence.

Authors:  Erika L Pearce; Edward J Pearce
Journal:  Immunity       Date:  2013-04-18       Impact factor: 31.745

Review 8.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

9.  Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Authors:  Ping-Chih Ho; Jessica Dauz Bihuniak; Andrew N Macintyre; Matthew Staron; Xiaojing Liu; Robert Amezquita; Yao-Chen Tsui; Guoliang Cui; Goran Micevic; Jose C Perales; Steven H Kleinstein; E Dale Abel; Karl L Insogna; Stefan Feske; Jason W Locasale; Marcus W Bosenberg; Jeffrey C Rathmell; Susan M Kaech
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582
  9 in total
  1 in total

Review 1.  Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.

Authors:  Mariona Cabo; Rienk Offringa; Laurence Zitvogel; Guido Kroemer; Aura Muntasell; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-08-30       Impact factor: 8.110
  1 in total

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